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  • Lipid-Based Drug Delivery Systems in Cancer Therapy: What Is Available and What Is Yet to Come

    Author(s)
    Yingchoncharoen, Phatsapong
    Kalinowski, Danuta S
    Richardson, Des R
    Griffith University Author(s)
    Richardson, Des R.
    Year published
    2016
    Metadata
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    Abstract
    Cancer is a leading cause of death in many countries around the world. However, the efficacy of current standard treatments for a variety of cancers is suboptimal. First, most cancer treatments lack specificity, meaning that these treatments affect both cancer cells and their normal counterparts. Second, many anticancer agents are highly toxic, and thus, limit their use in treatment. Third, a number of cytotoxic chemotherapeutics are highly hydrophobic, which limits their utility in cancer therapy. Finally, many chemotherapeutic agents exhibit short halflives that curtail their efficacy. As a result of these deficiencies, ...
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    Cancer is a leading cause of death in many countries around the world. However, the efficacy of current standard treatments for a variety of cancers is suboptimal. First, most cancer treatments lack specificity, meaning that these treatments affect both cancer cells and their normal counterparts. Second, many anticancer agents are highly toxic, and thus, limit their use in treatment. Third, a number of cytotoxic chemotherapeutics are highly hydrophobic, which limits their utility in cancer therapy. Finally, many chemotherapeutic agents exhibit short halflives that curtail their efficacy. As a result of these deficiencies, many current treatments lead to side effects, noncompliance, and patient inconvenience due to difficulties in administration. However, the application of nanotechnology has led to the development of effective nanosized drug delivery systems known commonly as nanoparticles. Among these delivery systems, lipid-based nanoparticles, particularly liposomes, have shown to be quite effective at exhibiting the ability to: 1) improve the selectivity of cancer chemotherapeutic agents; 2) lower the cytotoxicity of anticancer drugs to normal tissues, and thus, reduce their toxic side effects; 3) increase the solubility of hydrophobic drugs; and 4) offer a prolonged and controlled release of agents. This review will discuss the current state of lipid-based nanoparticle research, including the development of liposomes for cancer therapy, different strategies for tumor targeting, liposomal formulation of various anticancer drugs that are commercially available, recent progress in liposome technology for the treatment of cancer, and the next generation of lipidbased nanoparticles.
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    Journal Title
    Pharmacological Reviews
    Volume
    68
    Issue
    3
    DOI
    https://doi.org/10.1124/pr.115.012070
    Subject
    Pharmacology and pharmaceutical sciences
    Science & Technology
    Life Sciences & Biomedicine
    Pharmacology & Pharmacy
    Pegylated-Liposomal Doxorubicin
    Polymer Hybrid Nanoparticles
    Publication URI
    http://hdl.handle.net/10072/409232
    Collection
    • Journal articles

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