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  • Cryptocaryols A−H, α-Pyrone-Containing 1,3-Polyols from Cryptocarya sp. Implicated in Stabilizing the Tumor Suppressor Pdcd4

    Author(s)
    Grkovic, Tanja
    Blees, Johanna S.
    Colburn, Nancy H.
    Schmid, Tobias
    Thomas, Cheryl L.
    Henrich, Curtis J.
    McMahon, James B.
    Gustafson, Kirk R.
    Griffith University Author(s)
    Grkovic, Tanja
    Year published
    2011
    Metadata
    Show full item record
    Abstract
    A high-throughput cell-based reporter assay designed to identify smallmolecule stabilizers of the tumor suppressor Pdcd4 was used to screen extracts in the NCI Natural Products Repository. Bioassay-guided fractionation of an extract from a Papua New Guinea collection of the tropical tree Cryptocarya sp. provided a series of new 5,6-dihydro-alpha-pyrone-containing 1,3-polyols (1-8), named cryptocaryols A-H. Their structures were assigned from a combination of NMR, MS, and CD studies in conjunction with NMR database comparisons. Compounds 1-8 were found to rescue Pdcd4 from TPA-induced degradation with EC50 concentrations ...
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    A high-throughput cell-based reporter assay designed to identify smallmolecule stabilizers of the tumor suppressor Pdcd4 was used to screen extracts in the NCI Natural Products Repository. Bioassay-guided fractionation of an extract from a Papua New Guinea collection of the tropical tree Cryptocarya sp. provided a series of new 5,6-dihydro-alpha-pyrone-containing 1,3-polyols (1-8), named cryptocaryols A-H. Their structures were assigned from a combination of NMR, MS, and CD studies in conjunction with NMR database comparisons. Compounds 1-8 were found to rescue Pdcd4 from TPA-induced degradation with EC50 concentrations that ranged from 1.3 to 4.9 μM.
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    Journal Title
    Journal of Natural Products
    Volume
    74
    Issue
    5
    DOI
    https://doi.org/10.1021/np100918z
    Copyright Statement
    Self-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information.
    Subject
    Biologically Active Molecules
    Chemical Sciences
    Biological Sciences
    Medical and Health Sciences
    Publication URI
    http://hdl.handle.net/10072/40929
    Collection
    • Journal articles

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