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dc.contributor.authorFigueiredo, Vandre C
dc.contributor.authorRoberts, Llion A
dc.contributor.authorMarkworth, James F
dc.contributor.authorBarnett, Matthew PG
dc.contributor.authorCoombes, Jeff S
dc.contributor.authorRaastad, Truls
dc.contributor.authorPeake, Jonathan M
dc.contributor.authorCameron-Smith, David
dc.date.accessioned2021-10-21T00:27:26Z
dc.date.available2021-10-21T00:27:26Z
dc.date.issued2016
dc.identifier.issn2051-817X
dc.identifier.doi10.14814/phy2.12670
dc.identifier.urihttp://hdl.handle.net/10072/409328
dc.description.abstractMuscle hypertrophy occurs following increased protein synthesis, which requires activation of the ribosomal complex. Additionally, increased translational capacity via elevated ribosomal RNA (rRNA) synthesis has also been implicated in resistance training-induced skeletal muscle hypertrophy. The time course of ribosome biogenesis following resistance exercise (RE) and the impact exerted by differing recovery strategies remains unknown. In the present study, the activation of transcriptional regulators, the expression levels of pre-rRNA, and mature rRNA components were measured through 48 h after a single-bout RE. In addition, the effects of either low-intensity cycling (active recovery, ACT) or a cold-water immersion (CWI) recovery strategy were compared. Nine male subjects performed two bouts of high-load RE randomized to be followed by 10 min of either ACT or CWI. Muscle biopsies were collected before RE and at 2, 24, and 48 h after RE. RE increased the phosphorylation of the p38-MNK1-eIF4E axis, an effect only evident with ACT recovery. Downstream, cyclin D1 protein, total eIF4E, upstream binding factor 1 (UBF1), and c-Myc proteins were all increased only after RE with ACT. This corresponded with elevated abundance of the pre-rRNAs (45S, ITS-28S, ITS- 5.8S, and ETS-18S) from 24 h after RE with ACT. In conclusion, coordinated upstream signaling and activation of transcriptional factors stimulated prerRNA expression after RE. CWI, as a recovery strategy, markedly blunted these events, suggesting that suppressed ribosome biogenesis may be one factor contributing to the impaired hypertrophic response observed when CWI is used regularly after exercise.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherWILEY
dc.relation.ispartofissue2
dc.relation.ispartofjournalPhysiological Reports
dc.relation.ispartofvolume4
dc.subject.fieldofresearchZoology
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchMedical physiology
dc.subject.fieldofresearchcode3109
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode3208
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsPhysiology
dc.subject.keywordsCyclin D1
dc.subject.keywordshypertrophy
dc.titleImpact of resistance exercise on ribosome biogenesis is acutely regulated by post-exercise recovery strategies
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationFigueiredo, VC; Roberts, LA; Markworth, JF; Barnett, MPG; Coombes, JS; Raastad, T; Peake, JM; Cameron-Smith, D, Impact of resistance exercise on ribosome biogenesis is acutely regulated by post-exercise recovery strategies, Physiological Reports, 2016, 4 (2)
dc.date.updated2021-10-21T00:25:08Z
gro.hasfulltextNo Full Text
gro.griffith.authorRoberts, Llion A.


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