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dc.contributor.authorChitsazan, Arash
dc.contributor.authorFerguson, Blake
dc.contributor.authorRam, Ramesh
dc.contributor.authorMukhopadhyay, Pamela
dc.contributor.authorHandoko, Herlina Y
dc.contributor.authorGabrielli, Brian
dc.contributor.authorSoyer, Peter H
dc.contributor.authorMorahan, Grant
dc.contributor.authorWalker, Graeme J
dc.date.accessioned2021-10-21T00:31:19Z
dc.date.available2021-10-21T00:31:19Z
dc.date.issued2016
dc.identifier.issn1755-1471
dc.identifier.doi10.1111/pcmr.12487
dc.identifier.urihttp://hdl.handle.net/10072/409330
dc.description.abstractCongenital nevi develop before birth and sometimes cover large areas of the body. They are presumed to arise from the acquisition of a gene mutation in an embryonic melanocyte that becomes trapped in the dermis during development. Mice bearing the Cdk4R24C::Tyr-NRASQ61K transgenes develop congenital nevus-like lesions by post-natal day 10, from melanocytes escaping the confines of hair follicles. We interbred these mice with the collaborative cross (CC), a resource that enables identification of modifier genes for complex diseases (those where multiple genes are involved). We examined variation in nevus cell density in 66 CC strains and mapped a large-effect quantitative trait locus (QTL) controlling nevus cell density to murine chromosome 9. The best candidate for a gene that exacerbates congenital nevus development in the context of an NRAS mutation is Cdon, a positive regulator of sonic hedgehog (Shh) that is expressed mainly in keratinocytes.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherWILEY-BLACKWELL
dc.relation.ispartofpagefrom459
dc.relation.ispartofpageto464
dc.relation.ispartofissue4
dc.relation.ispartofjournalPigment Cell & Melanoma Research
dc.relation.ispartofvolume29
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode32
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsOncology
dc.subject.keywordsCell Biology
dc.subject.keywordsDermatology
dc.titleA mutation in the Cdon gene potentiates congenital nevus development mediated by NRAS(Q61K)
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationChitsazan, A; Ferguson, B; Ram, R; Mukhopadhyay, P; Handoko, HY; Gabrielli, B; Soyer, PH; Morahan, G; Walker, GJ, A mutation in the Cdon gene potentiates congenital nevus development mediated by NRAS(Q61K), Pigment Cell & Melanoma Research, 2016, 29 (4), pp. 459-464
dcterms.dateAccepted2016-05-07
dc.date.updated2021-10-21T00:29:44Z
gro.hasfulltextNo Full Text
gro.griffith.authorGabrielli, Brian


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