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  • Multiparameter analysis of naevi and primary melanomas identifies a subset of naevi with elevated markers of transformation

    Author(s)
    Fox, Carly
    Lambie, Duncan
    Wilmott, James S
    Pinder, Alex
    Pavey, Sandra
    Kim-Anh, Le Cao
    Akalin, Taner
    Karaarslan, Isil Kilinc
    Ozdemir, Fezal
    Scolyer, Richard A
    Yamada, Miko
    Soyer, H Peter
    Schaider, Helmut
    Gabrielli, Brian
    Griffith University Author(s)
    Gabrielli, Brian
    Year published
    2016
    Metadata
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    Abstract
    Here we have carried out a multiparameter analysis using a panel of 28 immunohistochemical markers to identify markers of transformation from benign and dysplastic naevus to primary melanoma in three separate cohorts totalling 279 lesions. We have identified a set of eight markers that distinguish naevi from melanoma. None of markers or parameters assessed differentiated benign from dysplastic naevi. Indeed, the naevi clustered tightly in terms of their immunostaining patterns whereas primary melanomas showed more diverse staining patterns. A small subset of histopathologically benign lesions had elevated levels of multiple ...
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    Here we have carried out a multiparameter analysis using a panel of 28 immunohistochemical markers to identify markers of transformation from benign and dysplastic naevus to primary melanoma in three separate cohorts totalling 279 lesions. We have identified a set of eight markers that distinguish naevi from melanoma. None of markers or parameters assessed differentiated benign from dysplastic naevi. Indeed, the naevi clustered tightly in terms of their immunostaining patterns whereas primary melanomas showed more diverse staining patterns. A small subset of histopathologically benign lesions had elevated levels of multiple markers associated with melanoma, suggesting that these represent naevi with an increased potential for transformation to melanoma.
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    Journal Title
    Pigment Cell & Melanoma Research
    Volume
    29
    Issue
    4
    DOI
    https://doi.org/10.1111/pcmr.12489
    Subject
    Biological sciences
    Biomedical and clinical sciences
    Science & Technology
    Life Sciences & Biomedicine
    Oncology
    Cell Biology
    Dermatology
    Publication URI
    http://hdl.handle.net/10072/409332
    Collection
    • Journal articles

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