Multiparameter analysis of naevi and primary melanomas identifies a subset of naevi with elevated markers of transformation
Author(s)
Fox, Carly
Lambie, Duncan
Wilmott, James S
Pinder, Alex
Pavey, Sandra
Kim-Anh, Le Cao
Akalin, Taner
Karaarslan, Isil Kilinc
Ozdemir, Fezal
Scolyer, Richard A
Yamada, Miko
Soyer, H Peter
Schaider, Helmut
Gabrielli, Brian
Griffith University Author(s)
Year published
2016
Metadata
Show full item recordAbstract
Here we have carried out a multiparameter analysis using a panel of 28 immunohistochemical markers to identify markers of transformation from benign and dysplastic naevus to primary melanoma in three separate cohorts totalling 279 lesions. We have identified a set of eight markers that distinguish naevi from melanoma. None of markers or parameters assessed differentiated benign from dysplastic naevi. Indeed, the naevi clustered tightly in terms of their immunostaining patterns whereas primary melanomas showed more diverse staining patterns. A small subset of histopathologically benign lesions had elevated levels of multiple ...
View more >Here we have carried out a multiparameter analysis using a panel of 28 immunohistochemical markers to identify markers of transformation from benign and dysplastic naevus to primary melanoma in three separate cohorts totalling 279 lesions. We have identified a set of eight markers that distinguish naevi from melanoma. None of markers or parameters assessed differentiated benign from dysplastic naevi. Indeed, the naevi clustered tightly in terms of their immunostaining patterns whereas primary melanomas showed more diverse staining patterns. A small subset of histopathologically benign lesions had elevated levels of multiple markers associated with melanoma, suggesting that these represent naevi with an increased potential for transformation to melanoma.
View less >
View more >Here we have carried out a multiparameter analysis using a panel of 28 immunohistochemical markers to identify markers of transformation from benign and dysplastic naevus to primary melanoma in three separate cohorts totalling 279 lesions. We have identified a set of eight markers that distinguish naevi from melanoma. None of markers or parameters assessed differentiated benign from dysplastic naevi. Indeed, the naevi clustered tightly in terms of their immunostaining patterns whereas primary melanomas showed more diverse staining patterns. A small subset of histopathologically benign lesions had elevated levels of multiple markers associated with melanoma, suggesting that these represent naevi with an increased potential for transformation to melanoma.
View less >
Journal Title
Pigment Cell & Melanoma Research
Volume
29
Issue
4
Subject
Biological sciences
Biomedical and clinical sciences
Science & Technology
Life Sciences & Biomedicine
Oncology
Cell Biology
Dermatology