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dc.contributor.authorFox, Carly
dc.contributor.authorLambie, Duncan
dc.contributor.authorWilmott, James S
dc.contributor.authorPinder, Alex
dc.contributor.authorPavey, Sandra
dc.contributor.authorKim-Anh, Le Cao
dc.contributor.authorAkalin, Taner
dc.contributor.authorKaraarslan, Isil Kilinc
dc.contributor.authorOzdemir, Fezal
dc.contributor.authorScolyer, Richard A
dc.contributor.authorYamada, Miko
dc.contributor.authorSoyer, H Peter
dc.contributor.authorSchaider, Helmut
dc.contributor.authorGabrielli, Brian
dc.date.accessioned2021-10-21T00:34:38Z
dc.date.available2021-10-21T00:34:38Z
dc.date.issued2016
dc.identifier.issn1755-1471
dc.identifier.doi10.1111/pcmr.12489
dc.identifier.urihttp://hdl.handle.net/10072/409332
dc.description.abstractHere we have carried out a multiparameter analysis using a panel of 28 immunohistochemical markers to identify markers of transformation from benign and dysplastic naevus to primary melanoma in three separate cohorts totalling 279 lesions. We have identified a set of eight markers that distinguish naevi from melanoma. None of markers or parameters assessed differentiated benign from dysplastic naevi. Indeed, the naevi clustered tightly in terms of their immunostaining patterns whereas primary melanomas showed more diverse staining patterns. A small subset of histopathologically benign lesions had elevated levels of multiple markers associated with melanoma, suggesting that these represent naevi with an increased potential for transformation to melanoma.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherWILEY
dc.relation.ispartofpagefrom444
dc.relation.ispartofpageto452
dc.relation.ispartofissue4
dc.relation.ispartofjournalPigment Cell & Melanoma Research
dc.relation.ispartofvolume29
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode32
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsOncology
dc.subject.keywordsCell Biology
dc.subject.keywordsDermatology
dc.titleMultiparameter analysis of naevi and primary melanomas identifies a subset of naevi with elevated markers of transformation
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationFox, C; Lambie, D; Wilmott, JS; Pinder, A; Pavey, S; Kim-Anh, LC; Akalin, T; Karaarslan, IK; Ozdemir, F; Scolyer, RA; Yamada, M; Soyer, HP; Schaider, H; Gabrielli, B, Multiparameter analysis of naevi and primary melanomas identifies a subset of naevi with elevated markers of transformation, Pigment Cell & Melanoma Research, 2016, 29 (4), pp. 444-452
dcterms.dateAccepted2016-05-04
dc.date.updated2021-10-21T00:33:23Z
gro.hasfulltextNo Full Text
gro.griffith.authorGabrielli, Brian


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