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dc.contributor.authorHettiarachchi, Samith
dc.contributor.authorMelroy, Gehan
dc.contributor.authorMudugamuwa, Amith
dc.contributor.authorSampath, Peshan
dc.contributor.authorPremachandra, Charith
dc.contributor.authorAmarasinghe, Ranjith
dc.contributor.authorDau, Van
dc.date.accessioned2021-10-21T06:22:13Z
dc.date.available2021-10-21T06:22:13Z
dc.date.issued2021
dc.identifier.issn0924-4247
dc.identifier.doi10.1016/j.sna.2021.113047
dc.identifier.urihttp://hdl.handle.net/10072/409380
dc.description.abstractLab on a Chip (LOC) devices minimize, integrate, automate, and parallelize laboratory functions such as mixing, separation, and incubation on a single chip. Droplet generation is one key aspect in LOC devices which allows to conduct various chemical and biochemical assays enabling biological cell studies, high throughput drug development, and diagnostic screenings. This paper presents, modelling, simulation, and experimentation of an active droplet generator that is widely used in LOC devices. The model geometry used in this study was based on a flow focusing method of droplet generation. Droplet generation from the numerical simulations was observed within flow rate ratios ranging from 0.2 to 4 using optimised droplet contraction width of the generator model. Subsequently, a prototype droplet generator was designed and developed from Polymethyl Methacrylate (PMMA) material using a layer-based fabrication method. Based on the experimental setup presented here, the calculated ratios of flow rates obtained for different voltage values have shown that the formation of droplets occur between flow rate ratios of 1.04 and 4.74. In addition, morphological parameters of the droplet images extracted from a digital image processing algorithm show that the mean diameter of the droplets decreases with decreasing flow rate ratios.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherElsevier
dc.relation.ispartofjournalSensors and Actuators A: Physical
dc.relation.ispartofvolume332
dc.subject.fieldofresearchElectrical engineering
dc.subject.fieldofresearchMaterials engineering
dc.subject.fieldofresearchMechanical engineering
dc.subject.fieldofresearchFluid mechanics and thermal engineering
dc.subject.fieldofresearchcode4008
dc.subject.fieldofresearchcode4016
dc.subject.fieldofresearchcode4017
dc.subject.fieldofresearchcode4012
dc.subject.keywordsScience & Technology
dc.subject.keywordsTechnology
dc.subject.keywordsEngineering, Electrical & Electronic
dc.subject.keywordsInstruments & Instrumentation
dc.subject.keywordsEngineering
dc.titleDesign and development of a microfluidic droplet generator with vision sensing for lab-on-a-chip devices
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationHettiarachchi, S; Melroy, G; Mudugamuwa, A; Sampath, P; Premachandra, C; Amarasinghe, R; Dau, V, Design and development of a microfluidic droplet generator with vision sensing for lab-on-a-chip devices, Sensors and Actuators A: Physical, 2021, 332
dcterms.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.date.updated2021-10-20T23:50:58Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2021 The Author(s). Published by Elsevier B.V. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International (CC BY-NC-ND 4.0) License, which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorDau, Van


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