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dc.contributor.authorBrown, Imogen
dc.contributor.authorRolnik, Daniel Lorber
dc.contributor.authorFernando, Shavi
dc.contributor.authorMenezes, Melody
dc.contributor.authorRamkrishna, Jayshree
dc.contributor.authorda Silva Costa, Fabricio
dc.contributor.authorMeagher, Simon
dc.date.accessioned2021-10-22T03:22:11Z
dc.date.available2021-10-22T03:22:11Z
dc.date.issued2021
dc.identifier.issn0197-3851
dc.identifier.doi10.1002/pd.6055
dc.identifier.urihttp://hdl.handle.net/10072/409389
dc.description.abstractOBJECTIVE: To determine the proportion of major fetal structural abnormalities that can be detected before 11 gestational weeks. METHODS: We conducted a retrospective study of individual patient files at a tertiary provider of obstetric and gynecological ultrasound in Melbourne, Australia. All patients who had a pre-cell-free DNA (pre-cfDNA) ultrasound with a crown-rump length (CRL) of less than 45mm and had one or more ultrasounds at a later gestation were included in the analysis. The primary outcome was the incidence of a fetal structural abnormality. RESULTS: A total of 3333 cases were included in the final analysis. Overall, 316 fetuses (9.5%) had a structural abnormality detected at any point throughout gestation, of which 86 were major structural abnormalities (2.6%). Sixteen fetal abnormalities were detected before 11 weeks of gestation, including fifteen major abnormalities (17.4% of the major anomalies). All major fetal abnormalities detected before 11 gestational weeks were confirmed at later ultrasound examinations or the pregnancy did not continue (in four cases due to termination of pregnancy and in one case spontaneous miscarriage before first trimester morphology ultrasound). CONCLUSION: Detection of fetal abnormalities is possible before 11 weeks of gestation. Early suspicion is more likely in cases of major structural abnormalities. This article is protected by copyright. All rights reserved.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherWiley
dc.relation.ispartofjournalPrenatal Diagnosis
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchPaediatrics
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode3213
dc.titleUltrasound findings and detection of fetal abnormalities before 11 weeks of gestation
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationBrown, I; Rolnik, DL; Fernando, S; Menezes, M; Ramkrishna, J; da Silva Costa, F; Meagher, S, Ultrasound findings and detection of fetal abnormalities before 11 weeks of gestation, Prenatal Diagnosis, 2021
dcterms.dateAccepted2021-09-29
dc.date.updated2021-10-22T00:55:00Z
gro.description.notepublicThis publication has been entered in Griffith Research Online as an advanced online version.
gro.hasfulltextNo Full Text
gro.griffith.authorDa Silva Costa, Fabricio


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