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dc.contributor.authorKistler-Fischbacher, Melanie
dc.contributor.authorYong, Jedidah S
dc.contributor.authorWeeks, Benjamin K
dc.contributor.authorBeck, Belinda R
dc.description.abstractPURPOSE: The goal of the MEDEX-OP trial was to compare the effectiveness of a high intensity resistance and impact training (HiRIT) program to a Pilates-based exercise program (Buff Bones®, BB), alone or in combination with antiresorptive bone medications, on indices of fracture risk (bone mineral density [BMD], body composition, muscle strength, functional performance). METHODS: Otherwise healthy postmenopausal women with low bone mass (T-score ≤ -1.0), screened for conditions known to influence bone and muscle health, who were on or off stable doses (≥ 12 months) of antiresorptive medication were recruited. One hundred and fifteen women (63.6 ± 0.7 years; BMI 25.5 kg/m2; FN T-score -1.8 ± 0.1) were randomly allocated to twice-weekly, 40-min, supervised HiRIT (5 sets of 5 repetitions at >80% 1 RM) or BB, stratified by medication intake, resulting in four groups: HiRIT (n = 42), BB (n = 44), HiRIT-med (n = 15), BB-med (n = 14). Analyses of covariance, adjusted for baseline age, were performed (data presented as mean ± SE). RESULTS: HiRIT but not BB improved lumbar spine BMD (1.9 ± 0.4% versus -0.6 ± 0.4%, p < 0.005), trochanteric BMD (2.9 ± 0.7 versus -0.6 ± 0.6, p = 0.002) and stature (0.2 ± 0.1 cm versus -0.0 ± 0.1 cm, p = 0.004). HiRIT-med improved BMD more than HiRIT alone at the femoral neck (4.9 ± 1.3% versus -0.0 ± 0.7%, p = 0.008) and total hip (2.2 ± 0.7% versus -0.5 ± 0.4%, p = 0.007). HiRIT and BB both improved muscle strength and functional performance but HiRIT effects were greater for isometric back muscle strength (31.8 ± 3.2% versus 14.4 ± 3.1%, p < 0.005) and five times sit-to-stand test (-11.8 ± 1.8% versus -3.8 ± 1.8%, p = 0.002). Both programs were well tolerated (7 adverse events: HiRIT, 3; BB, 4) and exercise compliance was good (82.4 ± 1.3%). CONCLUSION: High intensity resistance and impact training improved bone mass, muscle strength, functional performance and stature while Pilates-based exercise only improved functional performance. Combining osteoporosis medication with HiRIT may enhance effects on bone at the hip but more trials are needed to fully test the interaction.
dc.publisherLippincott Williams & Wilkins (LWW)
dc.relation.ispartofconferencetitleMedicine & Science in Sports & Exercise
dc.subject.fieldofresearchSports science and exercise
dc.subject.fieldofresearchMedical physiology
dc.subject.fieldofresearchExercise physiology
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.titleTargeted High-Intensity Exercise With And Without Osteoporosis Medications To Reduce Fracture Risk In Postmenopausal Women
dc.typeConference output
dc.type.descriptionE3 - Conferences (Extract Paper)
dcterms.bibliographicCitationKistler-Fischbacher, M; Yong, JS; Weeks, BK; Beck, BR, Targeted High-Intensity Exercise With And Without Osteoporosis Medications To Reduce Fracture Risk In Postmenopausal Women, Medicine & Science in Sports & Exercise, 2021, 53 (8), pp. 111-112
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gro.griffith.authorWeeks, Benjamin K.
gro.griffith.authorBeck, Belinda R.
gro.griffith.authorKistler-Fischbacher, Melanie
gro.griffith.authorYong, Jedidah S.

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