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  • HSV-1 enhances the energy metabolism of human umbilical cord mesenchymal stem cells to promote virus infection

    Author(s)
    Zhuo, Cuiqin
    Zheng, Danlin
    He, Zhe
    Jin, Ju
    Ren, Zhe
    Jin, Fujun
    Wang, Yifei
    Griffith University Author(s)
    Jin, Ju
    Year published
    2017
    Metadata
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    Abstract
    Aim: To explore the underlying influence of HSV type-1 (HSV-1) infection on the energy metabolism of human umbilical cord-derived mesenchymal stem cells (UCMSCs). Methods: UCMSCs (derived from different donors) were isolated from umbilical cord tissue, cultured and infected with HSV-1. Various virology and biochemical assays were used to assess cell viability and function, such as plaque formation assay and mitochondrial mass assay. Results: HSV-1 infection sharply activated mitochondrial biogenesis, increased glucose consumption, oxidative phosphorylation and glycolysis of UCMSCs. Treatment with rotenone (a metabolism ...
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    Aim: To explore the underlying influence of HSV type-1 (HSV-1) infection on the energy metabolism of human umbilical cord-derived mesenchymal stem cells (UCMSCs). Methods: UCMSCs (derived from different donors) were isolated from umbilical cord tissue, cultured and infected with HSV-1. Various virology and biochemical assays were used to assess cell viability and function, such as plaque formation assay and mitochondrial mass assay. Results: HSV-1 infection sharply activated mitochondrial biogenesis, increased glucose consumption, oxidative phosphorylation and glycolysis of UCMSCs. Treatment with rotenone (a metabolism antagonist) and iodoacetic acid significantly blocked the proliferation of HSV-1 in UCMSCs. Conclusion: This study demonstrates, for the first time, that HSV-1 infection affects the energy metabolism process of UCMSCs. Treatment with the appropriate metabolism antagonists might improve the safety and efficacy of clinical stem cell therapies.
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    Journal Title
    Future Virology
    Volume
    12
    Issue
    7
    DOI
    https://doi.org/10.2217/fvl-2017-0038
    Subject
    Microbiology
    Medical microbiology
    Science & Technology
    Life Sciences & Biomedicine
    Virology
    glycolysis
    HSV
    Publication URI
    http://hdl.handle.net/10072/409493
    Collection
    • Journal articles

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