dc.contributor.author | Campbell, A | |
dc.contributor.author | Gustafsson, L | |
dc.contributor.author | Grimley, R | |
dc.contributor.author | Gullo, H | |
dc.contributor.author | Rosbergen, I | |
dc.contributor.author | Summers, M | |
dc.date.accessioned | 2021-10-28T01:35:53Z | |
dc.date.available | 2021-10-28T01:35:53Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 1747-4930 | |
dc.identifier.uri | http://hdl.handle.net/10072/409506 | |
dc.description.abstract | Background:
Cognitive impairment is common post-stroke. There is a need to understand patterns of early cognitive recovery post-stroke to guide both clinical and research practice.
Aims:
To map the trajectory of cognitive recovery during the first week to 90-days post-stroke using serial computerised assessment.
Methods:
An observational cohort study recruited consecutive stroke patients admitted to a stroke unit within 48 hours of onset. Cognitive function was assessed using the computerised Cambridge Neuropsychological Test Automated Battery (CANTAB) daily for seven days, then 14, 30 and 90-days post-stroke. The CANTAB measured visual episodic memory and learning, information processing speed, visuo-spatial working memory, complex sustained attention, and mental flexibility. Repeated measures MANOVA/ANOVA with Least Squares Difference post-hoc analysis were performed to ascertain significant change over time.
Results:
Forty-eight participants with primarily mild, ischaemic stroke completed all time-points for analysis. For all subtests, significant improvement in performance was captured at multiple assessment points. In the first week post-stroke, a distinct period of early, rapid, global cognitive improvement was found, that largely stabilized between 8 and 14 days post mild stroke.
Conclusions:
Serial, computerised cognitive assessment can effectively map post-stroke cognitive recovery and revealed an early phase of rapid global improvement that is evidence for an acute post-stroke delirium. Post-stroke delirium appears to be far more common than is appreciated and can be measured. Resolution of post-stroke delirium in the second week following mild stroke indicates more extensive neuropsychological testing can be undertaken earlier than previously thought. | |
dc.language | English | |
dc.publisher | Sage Publications Ltd | |
dc.publisher.uri | https://journals.sagepub.com/doi/full/10.1177/17474930211036296 | |
dc.relation.ispartofconferencename | Stroke Society of Australasia Annual Scientific Meeting | |
dc.relation.ispartofconferencetitle | International Journal of Stroke | |
dc.relation.ispartofdatefrom | 2021-10-13 | |
dc.relation.ispartofdateto | 2021-10-15 | |
dc.relation.ispartoflocation | Perth Australia | |
dc.relation.ispartofpagefrom | 7 | |
dc.relation.ispartofpageto | 7 | |
dc.relation.ispartofissue | 1_suppl | |
dc.relation.ispartofvolume | 16 | |
dc.subject.fieldofresearch | Clinical sciences | |
dc.subject.fieldofresearch | Neurosciences | |
dc.subject.fieldofresearchcode | 3202 | |
dc.subject.fieldofresearchcode | 3209 | |
dc.subject.keywords | Science & Technology | |
dc.subject.keywords | Life Sciences & Biomedicine | |
dc.subject.keywords | Clinical Neurology | |
dc.subject.keywords | Peripheral Vascular Disease | |
dc.subject.keywords | Neurology | |
dc.title | Mapping the trajectory of acute post-stroke cognitive recovery | |
dc.type | Conference output | |
dc.type.description | E3 - Conferences (Extract Paper) | |
dcterms.bibliographicCitation | Campbell, A; Gustafsson, L; Grimley, R; Gullo, H; Rosbergen, I; Summers, M, Mapping the trajectory of acute post-stroke cognitive recovery, International Journal of Stroke, 2021, 16 (1_suppl), pp. 7-7 | |
dc.date.updated | 2021-10-27T22:14:25Z | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Gustafsson, Louise | |