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dc.contributor.authorCampbell, A
dc.contributor.authorGustafsson, L
dc.contributor.authorGrimley, R
dc.contributor.authorGullo, H
dc.contributor.authorRosbergen, I
dc.contributor.authorSummers, M
dc.description.abstractBackground: Cognitive impairment is common post-stroke. There is a need to understand patterns of early cognitive recovery post-stroke to guide both clinical and research practice. Aims: To map the trajectory of cognitive recovery during the first week to 90-days post-stroke using serial computerised assessment. Methods: An observational cohort study recruited consecutive stroke patients admitted to a stroke unit within 48 hours of onset. Cognitive function was assessed using the computerised Cambridge Neuropsychological Test Automated Battery (CANTAB) daily for seven days, then 14, 30 and 90-days post-stroke. The CANTAB measured visual episodic memory and learning, information processing speed, visuo-spatial working memory, complex sustained attention, and mental flexibility. Repeated measures MANOVA/ANOVA with Least Squares Difference post-hoc analysis were performed to ascertain significant change over time. Results: Forty-eight participants with primarily mild, ischaemic stroke completed all time-points for analysis. For all subtests, significant improvement in performance was captured at multiple assessment points. In the first week post-stroke, a distinct period of early, rapid, global cognitive improvement was found, that largely stabilized between 8 and 14 days post mild stroke. Conclusions: Serial, computerised cognitive assessment can effectively map post-stroke cognitive recovery and revealed an early phase of rapid global improvement that is evidence for an acute post-stroke delirium. Post-stroke delirium appears to be far more common than is appreciated and can be measured. Resolution of post-stroke delirium in the second week following mild stroke indicates more extensive neuropsychological testing can be undertaken earlier than previously thought.
dc.publisherSage Publications Ltd
dc.relation.ispartofconferencenameStroke Society of Australasia Annual Scientific Meeting
dc.relation.ispartofconferencetitleInternational Journal of Stroke
dc.relation.ispartoflocationPerth Australia
dc.subject.fieldofresearchClinical sciences
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsClinical Neurology
dc.subject.keywordsPeripheral Vascular Disease
dc.titleMapping the trajectory of acute post-stroke cognitive recovery
dc.typeConference output
dc.type.descriptionE3 - Conferences (Extract Paper)
dcterms.bibliographicCitationCampbell, A; Gustafsson, L; Grimley, R; Gullo, H; Rosbergen, I; Summers, M, Mapping the trajectory of acute post-stroke cognitive recovery, International Journal of Stroke, 2021, 16 (1_suppl), pp. 7-7
gro.hasfulltextNo Full Text
gro.griffith.authorGustafsson, Louise
gro.griffith.authorGrimley, Rohan

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    Contains papers delivered by Griffith authors at national and international conferences.

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