Show simple item record

dc.contributor.authorDomenighetti, Cloé
dc.contributor.authorSugier, Pierre-Emmanuel
dc.contributor.authorSreelatha, Ashwin Ashok Kumar
dc.contributor.authorSchulte, Claudia
dc.contributor.authorGrover, Sandeep
dc.contributor.authorMohamed, Océane
dc.contributor.authorPortugal, Berta
dc.contributor.authorMay, Patrick
dc.contributor.authorBobbili, Dheeraj R
dc.contributor.authorRadivojkov-Blagojevic, Milena
dc.contributor.authorLichtner, Peter
dc.contributor.authorSingleton, Andrew B
dc.contributor.authorHernandez, Dena G
dc.contributor.authorMellick, George D
dc.contributor.authoret al.
dc.date.accessioned2021-10-31T23:13:34Z
dc.date.available2021-10-31T23:13:34Z
dc.date.issued2021
dc.identifier.issn1877-7171
dc.identifier.doi10.3233/JPD-212851
dc.identifier.urihttp://hdl.handle.net/10072/409546
dc.description.abstractBACKGROUND: Previous studies showed that lifestyle behaviors (cigarette smoking, alcohol, coffee) are inversely associated with Parkinson's disease (PD). The prodromal phase of PD raises the possibility that these associations may be explained by reverse causation. OBJECTIVE: To examine associations of lifestyle behaviors with PD using two-sample Mendelian randomisation (MR) and the potential for survival and incidence-prevalence biases. METHODS: We used summary statistics from publicly available studies to estimate the association of genetic polymorphisms with lifestyle behaviors, and from Courage-PD (7,369 cases, 7,018 controls; European ancestry) to estimate the association of these variants with PD. We used the inverse-variance weighted method to compute odds ratios (ORIVW) of PD and 95%confidence intervals (CI). Significance was determined using a Bonferroni-corrected significance threshold (p = 0.017). RESULTS: We found a significant inverse association between smoking initiation and PD (ORIVW per 1-SD increase in the prevalence of ever smoking = 0.74, 95%CI = 0.60-0.93, p = 0.009) without significant directional pleiotropy. Associations in participants ≤67 years old and cases with disease duration ≤7 years were of a similar size. No significant associations were observed for alcohol and coffee drinking. In reverse MR, genetic liability toward PD was not associated with smoking or coffee drinking but was positively associated with alcohol drinking. CONCLUSION: Our findings are in favor of an inverse association between smoking and PD that is not explained by reverse causation, confounding, and survival or incidence-prevalence biases. Genetic liability toward PD was positively associated with alcohol drinking. Conclusions on the association of alcohol and coffee drinking with PD are hampered by insufficient statistical power.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherIOS Press
dc.relation.ispartofjournalJournal of Parkinson's Disease
dc.subject.fieldofresearchNeurology and neuromuscular diseases
dc.subject.fieldofresearchcode320905
dc.subject.keywordsParkinson’s disease
dc.subject.keywordsSmoking
dc.subject.keywordsalcohol
dc.subject.keywordscoffee
dc.subject.keywordsmendelian randomisation
dc.titleMendelian Randomisation Study of Smoking, Alcohol, and Coffee Drinking in Relation to Parkinson's Disease
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationDomenighetti, C; Sugier, P-E; Sreelatha, AAK; Schulte, C; Grover, S; Mohamed, O; Portugal, B; May, P; Bobbili, DR; Radivojkov-Blagojevic, M; Lichtner, P; Singleton, AB; Hernandez, DG; Mellick, GD; et al; Comprehensive Unbiaised Risk Factor Assessment for Genetics and Environment in Parkinson’s Disease (COURAGE-PD) consortium, , Mendelian Randomisation Study of Smoking, Alcohol, and Coffee Drinking in Relation to Parkinson's Disease, Journal of Parkinson's Disease, 2021
dc.date.updated2021-10-22T03:09:31Z
gro.description.notepublicThis publication has been entered in Griffith Research Online as an advanced online version.
gro.hasfulltextNo Full Text
gro.griffith.authorMellick, George


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record