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dc.contributor.authorConnaghan, F
dc.contributor.authorAvsar, P
dc.contributor.authorPatton, D
dc.contributor.authorO'Connor, T
dc.contributor.authorMoore, Z
dc.date.accessioned2021-11-01T05:06:01Z
dc.date.available2021-11-01T05:06:01Z
dc.date.issued2021
dc.identifier.issn0969-0700
dc.identifier.doi10.12968/jowc.2021.30.10.823
dc.identifier.urihttp://hdl.handle.net/10072/409602
dc.description.abstractObjective: The aim of this systematic review was to determine the impact of topical oxygen therapy (TOT) on diabetic foot ulcer (DFU) healing. Method: Using systematic review methodology, we considered randomised controlled trials (RCTs), controlled trials, pilot studies and observational studies. The search was conducted in January 2019, using PubMed, CINAHL, Ovid, Cochrane, Web of Science and EMBASE databases. Data analysis was undertaken using RevMan and a narrative synthesis. The article titles were assessed by two authors independently, and the abstracts (when available) of the studies identified by the search strategy were screened for their eligibility, according to the inclusion and exclusion criteria. The full-text version of potentially relevant studies was obtained and two authors independently screened this against the inclusion criteria. Data were extracted using a predesigned extraction tool and all included studies were quality appraised using the Evidence-Based Librarianship checklist. Results: The search returned 565 records of which eight met the inclusion criteria. Of the included studies, three were set in single centre outpatient wound clinics, two studies were set in an outpatient wound care research clinic and three studies were multisite. Meta-analysis of four studies was undertaken. DFUs are >2 times more likely to heal with TOT than with standard care alone. The odds ratio (OR)=2.49 (95% confidence interval (CI): 1.59-3.90, p=0.00001). The remaining four studies also showed that using TOT increased healing rates. An included study reported that time to 50% DFU closure was significantly shorter in participants who received the TOT, mean 18.4 days versus 28.9 days in the sham therapy group (p=0.001). However, the validity of 65.5% of the eight studies was assessed as low. Conclusion: The findings suggest that TOT enhances healing for patients with hard-to-heal DFUs when used with standard care. The results from the trials reviewed also indicate a benefit for patients over standard care alone. However, the sample sizes in the studies were generally small, thus, more RCTs are warranted to further validate these findings. Declaration of interest: The authors have no conflicts of interest to declare.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherMark Allen Group
dc.relation.ispartofpagefrom823
dc.relation.ispartofpageto829
dc.relation.ispartofissue10
dc.relation.ispartofjournalJournal of Wound Care
dc.relation.ispartofvolume30
dc.subject.fieldofresearchNursing
dc.subject.fieldofresearchEndocrinology
dc.subject.fieldofresearchcode4205
dc.subject.fieldofresearchcode320208
dc.subject.keywordsdiabetes
dc.subject.keywordsdiabetic foot ulcer
dc.subject.keywordsevidence-based librarianship checklist
dc.subject.keywordsrandomised controlled trial
dc.subject.keywordsstandard care
dc.titleImpact of topical oxygen therapy on diabetic foot ulcer healing rates: A systematic review
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationConnaghan, F; Avsar, P; Patton, D; O'Connor, T; Moore, Z, Impact of topical oxygen therapy on diabetic foot ulcer healing rates: A systematic review, Journal of Wound Care, 2021, 30 (10), pp. 823-829
dc.date.updated2021-10-27T23:12:45Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2021 MA Healthcare. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.hasfulltextFull Text
gro.griffith.authorPatton, Declan
gro.griffith.authorO'Connor, Tom
gro.griffith.authorMoore, Zena


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