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dc.contributor.authorMoorthy, V.en_US
dc.contributor.authorDiggs, C.en_US
dc.contributor.authorFerro, S.en_US
dc.contributor.authorGood, M.en_US
dc.contributor.authorHerrera, S.en_US
dc.contributor.authorHill, Adamen_US
dc.contributor.authorImoukhuede, E.en_US
dc.contributor.authorKumar, S.en_US
dc.contributor.authorLoucq, C.en_US
dc.contributor.authorMarsh, K.en_US
dc.contributor.authorOckenhouse, C.en_US
dc.contributor.authorRichie, T.en_US
dc.contributor.authorSauerwein, R.en_US
dc.description.abstractDevelopment and optimization of first generation malaria vaccine candidates has been facilitated by the existence of a well-established Plasmodium falciparum clinical challenge model in which infectious sporozoites are administered to human subjects via mosquito bite. While ideal for testing pre-erythrocytic stage vaccines, some researchers believe that the sporozoite challenge model is less appropriate for testing blood stage vaccines. Here we report a consultation, co-sponsored by PATH MVI, USAID, EMVI and WHO, where scientists from all institutions globally that have conducted such clinical challenges in recent years and representatives from regulatory agencies and funding agencies met to discuss clinical malaria challenge models. Participants discussed strengthening and harmonizing the sporozoite challenge model and considered the pros and cons of further developing a blood stage challenge possibly better suited for evaluating the efficacy of blood stage vaccines. This report summarizes major findings and recommendations, including an update on the Plasmodium vivax clinical challenge model, the prospects for performing experimental challenge trials in malaria endemic countries and an update on clinical safety data. While the focus of the meeting was on the optimization of clinical challenge models for evaluation of blood stage candidate malaria vaccines, many of the considerations are relevant for the application of challenge trials to other purposes.en_US
dc.publisherElsevier Ltden_US
dc.publisher.placeUnited Kingdomen_US
dc.subject.fieldofresearchBiological Sciences not elsewhere classifieden_US
dc.titleReport of a Consultation on the Optimization of Clinical Challenge Trials for Evaluation of Candidate Blood Stage Malaria Vaccines, 18–19 March 2009, Bethesda, MD, USAen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.hasfulltextNo Full Text

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