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dc.contributor.authorSaha, Subbroto Kumar
dc.contributor.authorIslam, SM Riazul
dc.contributor.authorSaha, Tripti
dc.contributor.authorNishat, Afsana
dc.contributor.authorBiswas, Polash Kumar
dc.contributor.authorGil, Minchan
dc.contributor.authorNkenyereye, Lewis
dc.contributor.authorEl-Sappagh, Shaker
dc.contributor.authorIslam, Md Saiful
dc.contributor.authorCho, Ssang-Goo
dc.date.accessioned2021-11-02T05:27:37Z
dc.date.available2021-11-02T05:27:37Z
dc.date.issued2021
dc.identifier.issn1976-670X
dc.identifier.doi10.5483/bmbrep.2021.54.10.087
dc.identifier.urihttp://hdl.handle.net/10072/409679
dc.description.abstractEGR1 (early growth response 1) is dysregulated in many cancers and exhibits both tumor suppressor and promoter activities, making it an appealing target for cancer therapy. Here, we used a systematic multi-omics analysis to review the expression of EGR1 and its role in regulating clinical outcomes in breast cancer (BC). EGR1 expression, its promoter methylation, and protein expression pattern were assessed using various publicly available tools. COSMIC-based somatic mutations and cBioPortal-based copy number alterations were analyzed, and the prognostic roles of EGR1 in BC were determined using Prognoscan and Kaplan-Meier Plotter. We also used bc-GenEx- Miner to investigate the EGR1 co-expression profile. EGR1 was more often downregulated in BC tissues than in normal breast tissue, and its knockdown was positively correlated with poor survival. Low EGR1 expression levels were also associated with increased risk of ER+, PR+, and HER2- BCs. High positive correlations were observed among EGR1, DUSP1, FOS, FOSB, CYR61, and JUN mRNA expression in BC tissue. This systematic review suggested that EGR1 expression may serve as a prognostic marker for BC patients and that clinicopathological parameters influence its prognostic utility. In addition to EGR1, DUSP1, FOS, FOSB, CYR61, and JUN can jointly be considered prognostic indicators for BC.
dc.description.peerreviewedYes
dc.languageen
dc.publisherKorean Society for Biochemistry and Molecular Biology - BMB Reports
dc.relation.ispartofpagefrom497
dc.relation.ispartofpageto504
dc.relation.ispartofissue10
dc.relation.ispartofjournalBMB Reports
dc.relation.ispartofvolume54
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchcode3211
dc.subject.fieldofresearchcode3101
dc.titlePrognostic role of EGR1 in breast cancer: a systematic review
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationSaha, SK; Islam, SMR; Saha, T; Nishat, A; Biswas, PK; Gil, M; Nkenyereye, L; El-Sappagh, S; Islam, MS; Cho, S-G, Prognostic role of EGR1 in breast cancer: a systematic review, BMB Reports, 2021, 54 (10), pp. 497-504
dcterms.licensehttps://creativecommons.org/licenses/by-nc/4.0/
dc.date.updated2021-11-02T01:37:30Z
gro.rights.copyright© 2021 by the Korean Society for Biochemistry and Molecular Biology. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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gro.griffith.authorIslam, Saiful


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