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dc.contributor.authorOrssatto, Lucas BR
dc.contributor.authorBorg, David N
dc.contributor.authorBlazevich, Anthony J
dc.contributor.authorSakugawa, Raphael L
dc.contributor.authorShield, Anthony J
dc.contributor.authorTrajano, Gabriel S
dc.date.accessioned2021-11-03T01:58:44Z
dc.date.available2021-11-03T01:58:44Z
dc.date.issued2021
dc.identifier.issn2509-2715
dc.identifier.doi10.1007/s11357-021-00478-z
dc.identifier.urihttp://hdl.handle.net/10072/409701
dc.description.abstractAge-related deterioration within both motoneuron and monoaminergic systems should theoretically reduce neuromodulation by weakening motoneuronal persistent inward current (PIC) amplitude. However, this assumption remains untested. Surface electromyographic signals were collected using two 32-channel electrode matrices placed on soleus and tibialis anterior of 25 older adults (70 ± 4 years) and 17 young adults (29 ± 5 years) to investigate motor unit discharge behaviors. Participants performed triangular-shaped plantar and dorsiflexion contractions to 20% of maximum torque at a rise-decline rate of 2%/s of each participant's maximal torque. Pairwise and composite paired-motor unit analyses were adopted to calculate delta frequency (ΔF), which has been used to differentiate between the effects of synaptic excitation and intrinsic motoneuronal properties and is assumed to be proportional to PIC amplitude. Soleus and tibialis anterior motor units in older adults had lower ΔFs calculated with either the pairwise [-0.99 and -1.46 pps; -35.4 and -33.5%, respectively] or composite (-1.18 and -2.28 pps; -32.1 and -45.2%, respectively) methods. Their motor units also had lower peak discharge rates (-2.14 and -2.03 pps; -19.7 and -13.9%, respectively) and recruitment thresholds (-1.50 and -2.06% of maximum, respectively) than young adults. These results demonstrate reduced intrinsic motoneuron excitability during low-force contractions in older adults, likely mediated by decreases in the amplitude of persistent inward currents. Our findings might be explained by deterioration in the motoneuron or monoaminergic systems and could contribute to the decline in motor function during aging; these assumptions should be explicitly tested in future investigations.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.relation.ispartofjournalGeroscience
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3202
dc.subject.keywordsAgeing
dc.subject.keywordsHD-EMG
dc.subject.keywordsMotor unit
dc.subject.keywordsMotor neurone
dc.subject.keywordsPersistent inward current
dc.titleIntrinsic motoneuron excitability is reduced in soleus and tibialis anterior of older adults
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationOrssatto, LBR; Borg, DN; Blazevich, AJ; Sakugawa, RL; Shield, AJ; Trajano, GS, Intrinsic motoneuron excitability is reduced in soleus and tibialis anterior of older adults, Geroscience, 2021
dcterms.dateAccepted2021-10-18
dc.date.updated2021-11-03T00:11:26Z
gro.description.notepublicThis publication has been entered in Griffith Research Online as an advanced online version.
gro.hasfulltextNo Full Text
gro.griffith.authorBorg, David


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