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dc.contributor.authorGarcia-Minambres, Albert
dc.contributor.authorEid, Sahar G
dc.contributor.authorMangan, Niamh E
dc.contributor.authorPade, Corinna
dc.contributor.authorLim, San S
dc.contributor.authorMatthews, Antony Y
dc.contributor.authorde Weerd, Nicole A
dc.contributor.authorHertzog, Paul J
dc.contributor.authorMak, Johnson
dc.date.accessioned2021-11-03T04:58:29Z
dc.date.available2021-11-03T04:58:29Z
dc.date.issued2017
dc.identifier.issn0818-9641
dc.identifier.doi10.1038/icb.2016.123
dc.identifier.urihttp://hdl.handle.net/10072/409724
dc.description.abstractInterferon epsilon (IFNɛ) is a type I IFN that is expressed constitutively in the female reproductive tract (FRT), and contributes to protection in models of sexually transmitted infections. Using multiple cell systems, including reporter cell lines and activated peripheral blood lymphocytes (PBLs), we show that recombinant IFNɛ impairs HIV infection at stage(s) post HIV entry and up to the translation of viral proteins. Consistent with this, IFNɛ upregulated a number of host cell restriction factors that block HIV at these stages of the replication cycle. The potency of IFNɛ induction of these HIV restriction factors was comparable to conventional type I IFNs, namely IFNα and IFNβ. IFNɛ also significantly reduced the infectivity of progeny virion particles likely by inducing expression of HIV restriction factors, such as IFITM3, which act at that stage of infection. Thus, our data demonstrate that human IFNɛ suppresses HIV replication at multiple stages of infection.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherJohn Wiley and Sons
dc.relation.ispartofpagefrom478
dc.relation.ispartofpageto483
dc.relation.ispartofissue5
dc.relation.ispartofjournalImmunology and Cell Biology
dc.relation.ispartofvolume95
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchImmunology
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode3204
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsCell Biology
dc.subject.keywordsFEMALE GENITAL-TRACT
dc.titleInterferon epsilon promotes HIV restriction at multiple steps of viral replication
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationGarcia-Minambres, A; Eid, SG; Mangan, NE; Pade, C; Lim, SS; Matthews, AY; de Weerd, NA; Hertzog, PJ; Mak, J, Interferon epsilon promotes HIV restriction at multiple steps of viral replication, Immunology and Cell Biology, 2017, 95 (5), pp. 478-483
dcterms.dateAccepted2016-12-12
dc.date.updated2021-11-03T04:56:17Z
gro.hasfulltextNo Full Text
gro.griffith.authorMak, Johnson


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