Show simple item record

dc.contributor.authorSun, Z
dc.contributor.authorZheng, S
dc.contributor.authorZhao, H
dc.contributor.authorNiu, Z
dc.contributor.authorLu, Y
dc.contributor.authorPan, Y
dc.contributor.authorYang, Y
dc.date.accessioned2021-11-04T00:51:41Z
dc.date.available2021-11-04T00:51:41Z
dc.date.issued2021
dc.identifier.issn1545-5963
dc.identifier.doi10.1109/TCBB.2021.3118916
dc.identifier.urihttp://hdl.handle.net/10072/409758
dc.description.abstractMotivation: The interactions of proteins with DNA, RNA, peptide, and carbohydrate play key roles in various biological processes. The studies of uncharacterized proteinmolecules interactions could be aided by accurate predictions of residues that bind with partner molecules. However, the existing methods for predicting binding residues on proteins remain of relatively low accuracies due to the limited number of complex structures in databases. As different types of molecules partially share chemical mechanisms, the predictions for each molecular type should benefit from the binding information with other molecules types. Results: In this study, we employed a multiple task deep learning strategy to develop a new sequence-based method for simultaneously predicting binding residues/sites with multiple important molecule types named MTDsite. By combining four training sets for DNA, RNA, peptide, and carbohydrate-binding proteins, our method yielded accurate and robust predictions with AUC values of 0.852, 0836, 0.758, and 0.776 on their respective independent test sets, which are 0.52 to 6.6% better than other state-of-the-art methods. To my best knowledge, this is the first method using multi-task framework to predict multiple molecular binding sites simultaneously. Availability: http://biomed.nscc-gz.cn/server/MTDsite/ Contact: yangyd25@mail.sysu.edu.cn
dc.description.peerreviewedYes
dc.publisherInstitute of Electrical and Electronics Engineers (IEEE)
dc.relation.ispartofjournalIEEE/ACM Transactions on Computational Biology and Bioinformatics
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchInformation and computing sciences
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode46
dc.titleTo improve the predictions of binding residues with DNA, RNA, carbohydrate, and peptide via multi-task deep neural networks
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationSun, Z; Zheng, S; Zhao, H; Niu, Z; Lu, Y; Pan, Y; Yang, Y, To improve the predictions of binding residues with DNA, RNA, carbohydrate, and peptide via multi-task deep neural networks, IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2021
dc.date.updated2021-11-04T00:45:29Z
dc.description.versionAccepted Manuscript (AM)
gro.description.notepublicThis publication has been entered as an advanced online version in Griffith Research Online.
gro.rights.copyright© 2021 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
gro.hasfulltextFull Text
gro.griffith.authorYang, Yuedong


Files in this item

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record