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  • Inter-lamellar nanostructures-by-design for high-performance dual-photoelectrode photofuel cell based genosensor

    Author(s)
    Sun, Yuping
    Li, Fen
    Liu, Xiaoqiang
    Qin, Tengteng
    Li, Tongtong
    Zheng, Hejie
    Alwarappan, Subbiah
    Ostrikov, Kostya Ken
    Griffith University Author(s)
    Ostrikov, Ken
    Year published
    2022
    Metadata
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    Abstract
    Photofuel cells (PFCs) that integrate “clean-solar-to-electric energy” and “sensing platform” can enable next-generation biosensors for diverse health care and environmental applications. However, the inferior performance of photoelectrodes often results in insufficient solar-to-power conversion for reliable molecular detection. To overcome this problem, we developed a PFC-based genosensor by combining a Ti3C2Tx|CdS photoanode and a CuInS2 photocathode to generate significant output power for the reliable detection of miRNA-21. The innovative photoanode design involves (i) the insertion of CdS nanorods into multi-layered ...
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    Photofuel cells (PFCs) that integrate “clean-solar-to-electric energy” and “sensing platform” can enable next-generation biosensors for diverse health care and environmental applications. However, the inferior performance of photoelectrodes often results in insufficient solar-to-power conversion for reliable molecular detection. To overcome this problem, we developed a PFC-based genosensor by combining a Ti3C2Tx|CdS photoanode and a CuInS2 photocathode to generate significant output power for the reliable detection of miRNA-21. The innovative photoanode design involves (i) the insertion of CdS nanorods into multi-layered Ti3C2Tx to expand the interlamellar space from ~0.98 to ~1.34 nm for accommodating more biomolecules to improve the sensor sensitivity; (ii) the formation of the nanoscale Schottky junction to enhance photo-generated charge separation and photoelectric conversion rates. The hybridization of capture DNA, assistant DNA and miRNA-21 on the photoanode led to the initial quenching of output signal of prepared PFC. As a mimic enzyme, manganese porphyrin was intercalated into the conjugated DNA double chains to catalyze a precipitation reaction on the photoanode surface, which resulted in a further signal quenching. Due to the combination of specially designed PFC with dual signal quenching, the proposed PFC-based genosensor exhibited a dynamic detection range of 1 fM to 0.01 μM with a LOD of 0.053 fM for detection of miRNA-21.
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    Journal Title
    Sensors and Actuators B: Chemical
    Volume
    350
    DOI
    https://doi.org/10.1016/j.snb.2021.130838
    Subject
    Analytical chemistry
    Materials engineering
    Atomic, molecular and optical physics
    Science & Technology
    Physical Sciences
    Chemistry, Analytical
    Electrochemistry
    Publication URI
    http://hdl.handle.net/10072/409770
    Collection
    • Journal articles

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