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dc.contributor.authorMcBride, A
dc.contributor.authorChanh, HQ
dc.contributor.authorFraser, JF
dc.contributor.authorYacoub, S
dc.contributor.authorObonyo, NG
dc.date.accessioned2021-11-04T02:16:12Z
dc.date.available2021-11-04T02:16:12Z
dc.date.issued2020
dc.identifier.issn2305-7823
dc.identifier.doi10.21542/GCSP.2020.29
dc.identifier.urihttp://hdl.handle.net/10072/409783
dc.description.abstractThe microcirculation comprising of arterioles, capillaries and post-capillary venules is the terminal vascular network of the systemic circulation. Microvascular homeostasis, comprising of a balance between vasoconstriction, vasodilation and endothelial permeability in healthy states, regulates tissue perfusion. In severe infections, systemic inflammation occurs irrespective of the infecting microorganism(s), resulting in microcirculatory dysregulation and dysfunction, which impairs tissue perfusion and often precedes end-organ failure. The common hallmarks of microvascular dysfunction in both septic shock and dengue shock, are endothelial cell activation, glycocalyx degradation and plasma leak through a disrupted endothelial barrier. Microvascular tone is also impaired by a reduced bioavailability of nitric oxide. In vitro and in vivo studies have however demonstrated that the nature and extent of microvascular dysfunction as well as responses to volume expansion resuscitation differ in these two clinical syndromes. This review compares and contrasts the pathophysiology of microcirculatory dysfunction in septic versus dengue shock and the attendant effects of fluid administration during resuscitation.
dc.description.peerreviewedYes
dc.publisherGlobal Cardiology Science and Practice
dc.relation.ispartofissue2
dc.relation.ispartofjournalGlobal Cardiology Science and Practice
dc.relation.ispartofvolume2020
dc.subject.fieldofresearchCardiology (incl. cardiovascular diseases)
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode320101
dc.subject.fieldofresearchcode3202
dc.titleMicrovascular dysfunction in septic and dengue shock: Pathophysiology and implications for clinical management
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationMcBride, A; Chanh, HQ; Fraser, JF; Yacoub, S; Obonyo, NG, Microvascular dysfunction in septic and dengue shock: Pathophysiology and implications for clinical management, Global Cardiology Science and Practice, 2021, 2020 (2)
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2021-11-04T02:04:23Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2020 The Author(s), licensee Magdi Yacoub Institute. This is an open access article distributed under the terms of the Creative Commons Attribution license CC BY-4.0, which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorFraser, John F.


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