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dc.contributor.authorMonjezi, M
dc.contributor.authorRismanian, M
dc.contributor.authorJamaati, H
dc.contributor.authorKashaninejad, N
dc.date.accessioned2021-11-04T05:51:39Z
dc.date.available2021-11-04T05:51:39Z
dc.date.issued2021
dc.identifier.issn2076-3417
dc.identifier.doi10.3390/app11209418
dc.identifier.urihttp://hdl.handle.net/10072/409795
dc.description.abstractThe up-and-coming microfluidic technology is the most promising platform for designing anti-cancer drugs and new point-of-care diagnostics. Compared to conventional drug screening methods based on Petri dishes and animal studies, drug delivery in microfluidic systems has many advantages. For instance, these platforms offer high-throughput drug screening, require a small number of samples, provide an in vivo-like microenvironment for cells, and eliminate ethical issues associated with animal studies. Multiple cell cultures in microfluidic chips could better mimic the 3D tumor environment using low reagents consumption. The clinical experiments have shown that combinatorial drug treatments have a better therapeutic effect than monodrug therapy. Many attempts have been made in this field in the last decade. This review highlights the applications of microfluidic chips in anti-cancer drug screening and systematically categorizes these systems as a function of sample size and combination of drug screening. Finally, it provides a perspective on the future of the clinical applications of microfluidic systems for anti-cancer drug development.
dc.description.peerreviewedYes
dc.languageen
dc.publisherMDPI AG
dc.relation.ispartofpagefrom9418
dc.relation.ispartofissue20
dc.relation.ispartofjournalApplied Sciences
dc.relation.ispartofvolume11
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchNanotechnology
dc.subject.fieldofresearchPublic health
dc.subject.fieldofresearchcode3211
dc.subject.fieldofresearchcode4018
dc.subject.fieldofresearchcode4206
dc.titleAnti-cancer drug screening with microfluidic technology
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationMonjezi, M; Rismanian, M; Jamaati, H; Kashaninejad, N, Anti-cancer drug screening with microfluidic technology, Applied Sciences, 2021, 11 (20), pp. 9418
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2021-11-04T03:32:27Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorKashaninejad, Navid


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