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dc.contributor.authorMillar, JE
dc.contributor.authorWildi, K
dc.contributor.authorBartnikowski, N
dc.contributor.authorBouquet, M
dc.contributor.authorHyslop, K
dc.contributor.authorPassmore, MR
dc.contributor.authorKi, KK
dc.contributor.authorSee Hoe, LE
dc.contributor.authorObonyo, NG
dc.contributor.authorNeyton, L
dc.contributor.authorPedersen, S
dc.contributor.authorRozencwajg, S
dc.contributor.authorBaillie, JK
dc.contributor.authorLi Bassi, G
dc.contributor.authorFraser, John F.
dc.contributor.authoret al.
dc.date.accessioned2021-11-04T06:29:45Z
dc.date.available2021-11-04T06:29:45Z
dc.date.issued2021
dc.identifier.issn2051-817X
dc.identifier.doi10.14814/phy2.15048
dc.identifier.urihttp://hdl.handle.net/10072/409799
dc.description.abstractThe acute respiratory distress syndrome (ARDS) describes a heterogenous population of patients with acute severe respiratory failure. However, contemporary advances have begun to identify distinct sub-phenotypes that exist within its broader envelope. These sub-phenotypes have varied outcomes and respond differently to several previously studied interventions. A more precise understanding of their pathobiology and an ability to prospectively identify them, may allow for the development of precision therapies in ARDS. Historically, animal models have played a key role in translational research, although few studies have so far assessed either the ability of animal models to replicate these sub-phenotypes or investigated the presence of sub-phenotypes within animal models. Here, in three ovine models of ARDS, using combinations of oleic acid and intravenous, or intratracheal lipopolysaccharide, we investigated the presence of sub-phenotypes which qualitatively resemble those found in clinical cohorts. Principal Component Analysis and partitional clustering identified two clusters, differentiated by markers of shock, inflammation, and lung injury. This study provides a first exploration of ARDS phenotypes in preclinical models and suggests a methodology for investigating this phenomenon in future studies.
dc.description.peerreviewedYes
dc.languageen
dc.publisherWiley
dc.relation.ispartofpagefrome15048
dc.relation.ispartofissue19
dc.relation.ispartofjournalPhysiological Reports
dc.relation.ispartofvolume9
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3202
dc.titleCharacterizing preclinical sub-phenotypic models of acute respiratory distress syndrome: An experimental ovine study
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationMillar, JE; Wildi, K; Bartnikowski, N; Bouquet, M; Hyslop, K; Passmore, MR; Ki, KK; See Hoe, LE; Obonyo, NG; Neyton, L; Pedersen, S; Rozencwajg, S; Baillie, JK; Li Bassi, G; Fraser, JF; et al., Characterizing preclinical sub-phenotypic models of acute respiratory distress syndrome: An experimental ovine study, Physiological Reports, 2021, 9 (19), pp. e15048
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2021-11-04T03:25:11Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2021 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorFraser, John F.
gro.griffith.authorSee Hoe, Louise


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