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  • Complete protection by a single-dose skin patch-delivered SARS-CoV-2 spike vaccine.

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    McMillan518778-Published.pdf (497.9Kb)
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    Version of Record (VoR)
    Author(s)
    McMillan, Christopher LD
    Choo, Jovin JY
    Idris, Adi
    Supramaniam, Aroon
    Modhiran, Naphak
    Amarilla, Alberto A
    Isaacs, Ariel
    Cheung, Stacey TM
    Liang, Benjamin
    Bielefeldt-Ohmann, Helle
    Azuar, Armira
    Acharya, Dhruba
    Kelly, Gabrielle
    Fernando, Germain JP
    Landsberg, Michael J
    et al.
    Griffith University Author(s)
    McMillan, Nigel
    Supramaniam, Aroon
    Acharya, Dhruba
    Year published
    2021
    Metadata
    Show full item record
    Abstract
    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected more than 160 million people and resulted in more than 3.3 million deaths, and despite the availability of multiple vaccines, the world still faces many challenges with their rollout. Here, we use the high-density microarray patch (HD-MAP) to deliver a SARS-CoV-2 spike subunit vaccine directly to the skin. We show that the vaccine is thermostable on the patches, with patch delivery enhancing both cellular and antibody immune responses. Elicited antibodies potently neutralize clinically relevant isolates including the Alpha and Beta variants. Last, a ...
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    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected more than 160 million people and resulted in more than 3.3 million deaths, and despite the availability of multiple vaccines, the world still faces many challenges with their rollout. Here, we use the high-density microarray patch (HD-MAP) to deliver a SARS-CoV-2 spike subunit vaccine directly to the skin. We show that the vaccine is thermostable on the patches, with patch delivery enhancing both cellular and antibody immune responses. Elicited antibodies potently neutralize clinically relevant isolates including the Alpha and Beta variants. Last, a single dose of HD-MAP–delivered spike provided complete protection from a lethal virus challenge in an ACE2-transgenic mouse model. Collectively, these data show that HD-MAP delivery of a SARS-CoV-2 vaccine was superior to traditional needle-and-syringe vaccination and may be a significant addition to the ongoing COVID-19 (coronavirus disease 2019) pandemic.
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    Journal Title
    Science Advances
    Volume
    7
    Issue
    44
    DOI
    https://doi.org/10.1126/sciadv.abj8065
    Copyright Statement
    © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).
    Subject
    Epidemiology
    Virology
    Publication URI
    http://hdl.handle.net/10072/409800
    Collection
    • Journal articles

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