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dc.contributor.authorChuah, Candy
dc.contributor.authorJones, Malcolm K
dc.contributor.authorMcManus, Donald P
dc.contributor.authorNawaratna, Sujeevi K
dc.contributor.authorBurke, Melissa L
dc.contributor.authorOwen, Helen C
dc.contributor.authorRamm, Grant A
dc.contributor.authorGobert, Geoffrey N
dc.date.accessioned2021-11-05T02:32:58Z
dc.date.available2021-11-05T02:32:58Z
dc.date.issued2016
dc.identifier.issn0020-7519
dc.identifier.doi10.1016/j.ijpara.2015.12.004
dc.identifier.urihttp://hdl.handle.net/10072/409840
dc.description.abstractFor hepatic schistosomiasis the egg-induced granulomatous response and the development of extensive fibrosis are the main pathologies. We used a Schistosoma japonicum-infected mouse model to characterise the multi-cellular pathways associated with the recovery from hepatic fibrosis following clearance of the infection with the anti-schistosomal drug, praziquantel. In the recovering liver splenomegaly, granuloma density and liver fibrosis were all reduced. Inflammatory cell infiltration into the liver was evident, and the numbers of neutrophils, eosinophils and macrophages were significantly decreased. Transcriptomic analysis revealed the up-regulation of fatty acid metabolism genes and the identification of Peroxisome proliferator activated receptor alpha as the upstream regulator of liver recovery. The aryl hydrocarbon receptor signalling pathway which regulates xenobiotic metabolism was also differentially up-regulated. These findings provide a better understanding of the mechanisms associated with the regression of hepatic schistosomiasis.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherElsevier
dc.relation.ispartofpagefrom239
dc.relation.ispartofpageto252
dc.relation.ispartofissue4
dc.relation.ispartofjournalInternational Journal for Parasitology
dc.relation.ispartofvolume46
dc.subject.fieldofresearchMicrobiology
dc.subject.fieldofresearchZoology
dc.subject.fieldofresearchVeterinary sciences
dc.subject.fieldofresearchcode3107
dc.subject.fieldofresearchcode3109
dc.subject.fieldofresearchcode3009
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsParasitology
dc.subject.keywordsSchistosomiasis
dc.subject.keywordsHepatic fibrosis
dc.titleCharacterising granuloma regression and liver recovery in a murine model of schistosomiasis japonica
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationChuah, C; Jones, MK; McManus, DP; Nawaratna, SK; Burke, ML; Owen, HC; Ramm, GA; Gobert, GN, Characterising granuloma regression and liver recovery in a murine model of schistosomiasis japonica, International Journal for Parasitology, 2016, 46 (4), pp. 239-252
dcterms.dateAccepted2015-12-07
dc.date.updated2021-11-05T02:31:39Z
gro.hasfulltextNo Full Text
gro.griffith.authorNawaratna, Sujeevi S.


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