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dc.contributor.authorCheng, Tracie
dc.contributor.authorLam, Alfred K
dc.contributor.authorGopalan, Vinod
dc.date.accessioned2021-11-09T01:49:48Z
dc.date.available2021-11-09T01:49:48Z
dc.date.issued2021
dc.identifier.issn1040-8428
dc.identifier.doi10.1016/j.critrevonc.2021.103522
dc.identifier.urihttp://hdl.handle.net/10072/409976
dc.description.abstractPolycyclic aromatic hydrocarbon (PAHs) are molecules that contaminate meat products during the high-temperature cooking of meat. This study reviewed the pathogenic roles of meat derived polycyclic aromatic hydrocarbons in the carcinogenesis of colorectal cancer (CRC). Ingested PAHs undergo xenobiotic metabolism resulting in the activation of genotoxic metabolites that can induce DNA damage in the colorectum. Genetic polymorphisms in PAH xenobiotic enzymes are linked to the risk of CRC and suggest a role for PAH-meat ingestion in carcinogenesis of colorectal malignancies. Furthermore, PAH specific DNA adducts have been identified in colorectal cancer tissue and linked to high meat intake. DNA adduct resolution is mediated by the nucleotide excision repair, and polymorphisms within genes of this repair pathway and high meat intake are associated with increased CRC risk. In the literature, there is evidence from metabolic enzyme gene variants, DNA repair genes, PAH metabolites, and epidemiological studies suggesting PAH involvement in CRC.
dc.description.peerreviewedYes
dc.languageen
dc.publisherElsevier BV
dc.relation.ispartofpagefrom103522
dc.relation.ispartofjournalCritical Reviews in Oncology/Hematology
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchcode3211
dc.titleDiet derived polycyclic aromatic hydrocarbons and its pathogenic roles in colorectal carcinogenesis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationCheng, T; Lam, AK; Gopalan, V, Diet derived polycyclic aromatic hydrocarbons and its pathogenic roles in colorectal carcinogenesis, Critical Reviews in Oncology/Hematology, 2021, pp. 103522
dcterms.licensehttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.date.updated2021-11-08T01:17:43Z
dc.description.versionAccepted Manuscript (AM)
gro.description.notepublicThis publication has been entered in Griffith Research Online as an advanced online version.
gro.rights.copyright© 2021 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorLam, Alfred K.
gro.griffith.authorGopalan, Vinod
gro.griffith.authorCheng, Tracie T.


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