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dc.contributor.authorWertaschnigg, D
dc.contributor.authorReddy, M
dc.contributor.authorRamkrishna, J
dc.contributor.authorda Silva Costa, F
dc.contributor.authorSepulveda, W
dc.contributor.authorRolnik, DL
dc.contributor.authorMeagher, S
dc.description.abstractObjectives: The acrania-anencephaly sequence is a lethal condition with a high detection rate in experienced hands after 10 weeks’ gestation. However, earlier in gestation, many cases remain undetected. Different phenotypic appearances have been described and might help increase the detection rate in less experienced hands and also earlier in gestation. The purpose of this study was to assess interobserver reliability in classifying cases of the acrania-anencephaly sequence during first trimester in 6 different subtypes according to their ultrasound appearances. Methods: This was a retrospective descriptive cohort study at 3 centers for fetal imaging. Each case was classified according to its phenotypic appearance by 2 independent operators as “bilobular,” “cystic,” “elongated,” “irregular,” “foreshortened,” or “overhanging.” Frequencies of each type are described, and interoperator agreement was assessed with the intraclass correlation coefficient. Results: From the 88 included cases, the frequencies of the different subtypes classified as overhanging, elongated, bilobular, cystic, foreshortened, and irregular were 31%, 25%, 19%, 11%, 8%, and 6%, respectively. The interoperator reliability was good, with an intraclass correlation coefficient of 0.903 (95% confidence interval, 0.853–0.937; P <.001). Conclusions: Using different subtypes may improve the detection of the acrania-anencephaly sequence. An accurate early diagnosis could lead to timely, less traumatic, and safer management of affected pregnancies.en_US
dc.relation.ispartofjournalJournal of Ultrasound in Medicineen_US
dc.subject.fieldofresearchClinical sciencesen_US
dc.subject.keywordsacrania-anencephaly sequenceen_US
dc.subject.keywordsdetection rateen_US
dc.subject.keywordsfirst-trimester ultrasounden_US
dc.subject.keywordsprenatal diagnosisen_US
dc.titleUltrasound Appearances of the Acrania-Anencephaly Sequence at 10 to 14 Weeks’ Gestationen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationWertaschnigg, D; Reddy, M; Ramkrishna, J; da Silva Costa, F; Sepulveda, W; Rolnik, DL; Meagher, S, Ultrasound Appearances of the Acrania-Anencephaly Sequence at 10 to 14 Weeks’ Gestation, Journal of Ultrasound in Medicine, 2020, 39 (9), pp. 1695-1700en_US
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gro.griffith.authorDa Silva Costa, Fabricio

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