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dc.contributor.authorHolmes, Roger S
dc.contributor.authorSpradling-Reeves, Kimberly D
dc.contributor.authorCox, Laura A
dc.date.accessioned2021-11-15T02:26:51Z
dc.date.available2021-11-15T02:26:51Z
dc.date.issued2016
dc.identifier.issn2329-9002en_US
dc.identifier.doi10.4172/2329-9002.1000167en_US
dc.identifier.urihttp://hdl.handle.net/10072/410083
dc.description.abstractSLC9B genes and proteins are members of the sodium/lithium hydrogen antiporter family which function as solute exchangers within cellular membranes of mammalian tissues. SLC9B2 and SLC9B1 amino acid sequences and structures and SLC9B-like gene locations were examined using bioinformatic data from several vertebrate genome projects. Vertebrate SLC9B2 sequences shared 56-98% identity as compared with ∼50% identities with mammalian SLC9B1 sequences. Sequence alignments, key amino acid residues and conserved predicted transmembrane structures were also studied. Mammalian SLC9B2 and SLC9B1 genes usually contained 11 or 12 coding exons with differential tissue expression patterns: SLC9B2, broad tissue distribution; and SLC9B1, being testis specific. Transcription factor binding sites and CpG islands within the human SLC9B2 and SLC9B1 gene promoters were identified. Phylogenetic analyses suggested that SLC9B1 originated in an ancestral marsupial genome from a SLC9B2 gene duplication event.en_US
dc.description.peerreviewedYesen_US
dc.languageengen_US
dc.publisherHilarisen_US
dc.relation.ispartofpagefrom1000167en_US
dc.relation.ispartofissue3en_US
dc.relation.ispartofjournalJournal of Phylogenetics & Evolutionary Biologyen_US
dc.relation.ispartofvolume4en_US
dc.subject.fieldofresearchBiomedical and clinical sciencesen_US
dc.subject.fieldofresearchcode32en_US
dc.subject.keywordsGene evolutionen_US
dc.subject.keywordsMarsupial originen_US
dc.subject.keywordsNHA1en_US
dc.subject.keywordsNHA2en_US
dc.subject.keywordsSLC9B1en_US
dc.titleEvolution of vertebrate solute carrier family 9B genes and proteins (SLC9B): Evidence for a marsupial origin for testis specific SLC9B1 from an ancestral vertebrate SLC9B2 geneen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationHolmes, RS; Spradling-Reeves, KD; Cox, LA, Evolution of vertebrate solute carrier family 9B genes and proteins (SLC9B): Evidence for a marsupial origin for testis specific SLC9B1 from an ancestral vertebrate SLC9B2 gene, Journal of Phylogenetics & Evolutionary Biology, 2016, 4 (3), pp. 1000167en_US
dc.date.updated2021-11-15T02:21:56Z
gro.hasfulltextNo Full Text
gro.griffith.authorHolmes, Roger S.


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