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  • The carbohydrate CT1 is expressed in topographically fixed glomeruli in the mouse olfactory bulb

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    Author(s)
    Lineburg, Katie E
    Amaya, Daniel
    Ekberg, Jenny A
    Chehrehasa, Fatemeh
    Mackay-Sim, Alan
    Martin, Paul T
    Key, Brian
    St John, James A
    Griffith University Author(s)
    Mackay-Sim, Alan
    Amaya, Daniel A.
    Chehrehasa, Fatemeh
    St John, James A.
    Lineburg, Katie E.
    Ekberg, Jenny A.
    Year published
    2011
    Metadata
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    Abstract
    Cell surface carbohydrates define subpopulations of primary olfactory neurons whose axons terminate in select glomeruli in the olfactory bulb. The combination of carbohydrates present on axon subpopulations has been proposed to confer a unique identity that contributes to the establishment of the olfactory topographic map. We have identified a novel subpopulation of primary olfactory neurons in mice that express blood group carbohydrates with GalNAc-߱,4[NeuAca 2,3]Gal߱ residues recognised by the CT1 antibody. The CT1 carbohydrate has been shown to modulate adhesion of nerve terminals to the extracellular matrix and to synaptic ...
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    Cell surface carbohydrates define subpopulations of primary olfactory neurons whose axons terminate in select glomeruli in the olfactory bulb. The combination of carbohydrates present on axon subpopulations has been proposed to confer a unique identity that contributes to the establishment of the olfactory topographic map. We have identified a novel subpopulation of primary olfactory neurons in mice that express blood group carbohydrates with GalNAc-߱,4[NeuAca 2,3]Gal߱ residues recognised by the CT1 antibody. The CT1 carbohydrate has been shown to modulate adhesion of nerve terminals to the extracellular matrix and to synaptic proteins. The axons of the CT1-positive primary olfactory neurons terminate in a subpopulation of glomeruli in the olfactory bulb. Four lines of evidence support the view that CT1 glomeruli are topographically fixed. First, CT1 glomeruli were restricted predominantly to the dorsomedial olfactory bulb and were absent from large patches of the ventrolateral bulb. Second, similar distributions were observed for CT1 glomeruli on both the left and right olfactory bulbs of each animal, and between animals. Third, CT1 glomeruli were typically present as small clusters of 2-4 glomeruli. Fourth, a single CT1 glomerulus was always apposed to the glomeruli innervated by axons expressing the M72 odorant receptor. We also show that the CT1 carbohydrate is lost in gain-of-function transgenic mice over-expressing the blood group A glycosyltransferase in which there is aberrant targeting of M72 axons. Taken together, these results suggest that the CT1 carbohydrate, together with other carbohydrates, contributes to axon guidance during the establishment of the olfactory topographic map.
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    Journal Title
    Molecular and Cellular Neuroscience
    Volume
    48
    Issue
    1
    DOI
    https://doi.org/10.1016/j.mcn.2011.05.011
    Copyright Statement
    © 2011 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
    Subject
    Peripheral Nervous System
    Central Nervous System
    Neurosciences
    Psychology
    Cognitive Sciences
    Publication URI
    http://hdl.handle.net/10072/41010
    Collection
    • Journal articles

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