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dc.contributor.authorFridman, M
dc.contributor.authorKrasko, O
dc.contributor.authorLevin, L
dc.contributor.authorVeyalkin, I
dc.contributor.authorLam, AKY
dc.date.accessioned2021-11-17T22:33:31Z
dc.date.available2021-11-17T22:33:31Z
dc.date.issued2021
dc.identifier.issn0344-0338
dc.identifier.doi10.1016/j.prp.2021.153658
dc.identifier.urihttp://hdl.handle.net/10072/410169
dc.description.abstractThe aim was to study the pathological features of papillary thyroid carcinoma diagnosed with or before second primary malignancy in patients exposed to post-Chernobyl exposure. The patients selected (n = 6559) were those exposed to radiation at the age of ≤ 18 years old and developed papillary thyroid carcinoma during the years 1990–2020. Of these, 2.1% (n = 140) had second primary malignancies. To compare the histopathological characteristics of papillary thyroid carcinoma in the group under analysis, 91% (n = 128) with sufficient data were included in further analysis. The control group was formed by matching patients with age at exposure to radiation, age at surgery, gender, and place of residence. Median age at exposure was 14 years old for both groups. Besides, no difference in tumour extension and histological features of papillary thyroid carcinoma was noted between patients with synchronous or metachronous primary malignant tumours. Nevertheless, the time lag to the diagnosis of papillary thyroid carcinoma was shortened in the group with metachronous when compared to patients with synchronous second primaries (p < 0.001). Independent differences between patients with second primaries and their matched peers included tumour size {OR (95%CI) = 0.89 (0.45; 1.04)}, multiple tumours {OR (95% CI) = 1.46 (0.86; 2.42)}, lymphatic vessel invasion (OR (95%CI) 0.92 (0.61; 1.53)), blood vessel invasion (OR (95%CI) 0.41 (0.10; 1.23) and presence of numerous psammomas (OR (95%CI) 0.73 (0.39; 1.31)). The possible influence of radiative iodine treatment for development of second primaries was analysed for the group of patients with metachronous malignancies using the same approach (84 patients were compared to 252 matched patients). Independent differences also included tumour size {OR (95% CI) 0.77 (0.45; 1.30)}, lymphatic vessel invasion {OR (95%CI) 0.75(0.43; 1.28)}, blood vessel invasion {OR (95%CI) 0.17 (0.01; 0.87)}. Besides, multiple tumours were revealed more frequently in patients with metachronous primaries (OR (95%CI) 1.92 (1.0; 3.62)). To conclude, patients exposed to Chernobyl irradiation with the development of papillary thyroid carcinoma and second primary malignancy have less biological aggressive pathological characteristics of their thyroid cancers. Accordingly, these patients were less frequently treated with post-surgical radioactive iodine. Thus, 131I-irradiation may have negligible impact on the development of second primaries.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherElsevier BV
dc.relation.ispartofpagefrom153658
dc.relation.ispartofjournalPathology - Research and Practice
dc.relation.ispartofvolume228
dc.subject.fieldofresearchPathology (excl. oral pathology)
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchcode320220
dc.subject.fieldofresearchcode3211
dc.subject.keywordsChernobyl
dc.subject.keywordsPapillary thyroid carcinoma
dc.subject.keywordsRadiation
dc.subject.keywordsSecondary cancer
dc.subject.keywordsThyroid
dc.titleComparative pathological characteristics of papillary thyroid carcinoma with second primary non-thyroid malignancies in the region affected by the Chernobyl accident
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationFridman, M; Krasko, O; Levin, L; Veyalkin, I; Lam, AKY, Comparative pathological characteristics of papillary thyroid carcinoma with second primary non-thyroid malignancies in the region affected by the Chernobyl accident, Pathology - Research and Practice, 2021, 228, pp. 153658
dcterms.dateAccepted2021-10-12
dcterms.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.date.updated2021-11-16T21:33:27Z
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2021 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorLam, Alfred K.


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