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  • Salivary High-Risk Human Papillomavirus (HPV) DNA as a Biomarker for HPV-Driven Head and Neck Cancers

    Author(s)
    Ekanayake Weeramange, C
    Liu, Z
    Hartel, G
    Li, Y
    Vasani, S
    Langton-Lockton, J
    Kenny, L
    Morris, L
    Frazer, I
    Tang, KD
    Punyadeera, C
    Griffith University Author(s)
    Punyadeera, Chamindie
    Weeramange, Chameera
    Year published
    2021
    Metadata
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    Abstract
    High-risk human papillomavirus (HR-HPV) infection is a major risk factor of head and neck cancers (HNCs). Despite the rising prevalence of HPV-driven HNC (HPV-HNC), biomarkers for detection, prognostication, and disease monitoring are lacking. To evaluate the capacity of salivary HR-HPV DNA as a biomarker of HPV-HNC, the salivary HR-HPV statuses of 491 and 10 patients with primary and recurrent HNC, respectively, were determined at diagnosis, using quantitative real-time PCR and MassARRAY. Tumor cyclin-dependent kinase inhibitor 2A (p16) expression was determined by IHC analysis. Patients with oropharyngeal cancer (OPC) (n ...
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    High-risk human papillomavirus (HR-HPV) infection is a major risk factor of head and neck cancers (HNCs). Despite the rising prevalence of HPV-driven HNC (HPV-HNC), biomarkers for detection, prognostication, and disease monitoring are lacking. To evaluate the capacity of salivary HR-HPV DNA as a biomarker of HPV-HNC, the salivary HR-HPV statuses of 491 and 10 patients with primary and recurrent HNC, respectively, were determined at diagnosis, using quantitative real-time PCR and MassARRAY. Tumor cyclin-dependent kinase inhibitor 2A (p16) expression was determined by IHC analysis. Patients with oropharyngeal cancer (OPC) (n = 215) were followed up for ≤5 years. Survival characteristics were evaluated in terms of event-free and cause-specific survival. Of the primary-HNC cohort, 43.2% were positive for salivary HR-HPV DNA, with most having OPC. Salivary HR-HPV DNA was detected in 81.4% of tumor p16–positive OPC patients at diagnosis. Prognosis in salivary HR-HPV–positive OPC patients was favorable compared with that in salivary HR-HPV–negative patients (event-free survival, hazard ratio = 0.42 [95% CI, 0.21–0.81, P = 0.010]; cause-specific survival, hazard ratio = 0.39 [95% CI, 0.18–0.86, P = 0.019]). In the recurrent-HNC cohort, salivary HR-HPV DNA was detected in 83.3% of those who previously had tumor p16–positive HNC. These findings indicate that this liquid biopsy–based, noninvasive biomarker can play an essential role in the detection and management of HPV-HNC.
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    Journal Title
    Journal of Molecular Diagnostics
    Volume
    23
    Issue
    10
    DOI
    https://doi.org/10.1016/j.jmoldx.2021.07.005
    Subject
    Medical microbiology
    Publication URI
    http://hdl.handle.net/10072/410178
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    • Journal articles

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