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dc.contributor.authorBeesley, Max A
dc.contributor.authorDavidson, Joseph R
dc.contributor.authorPanariello, Francesco
dc.contributor.authorShibuya, Soichi
dc.contributor.authorScaglioni, Dominic
dc.contributor.authorJones, Brendan C
dc.contributor.authorMaksym, Katarzyna
dc.contributor.authorOgunbiyi, Olumide
dc.contributor.authorSebire, Neil J
dc.contributor.authorCacchiarelli, Davide
dc.contributor.authorDavid, Anna L
dc.contributor.authorDe Coppi, Paolo
dc.contributor.authorGerli, Mattia FM
dc.date.accessioned2021-11-22T04:50:40Z
dc.date.available2021-11-22T04:50:40Z
dc.date.issued2021
dc.identifier.issn1470-0328
dc.identifier.doi10.1111/1471-0528.16974
dc.identifier.urihttp://hdl.handle.net/10072/410296
dc.description.abstractBACKGROUND: While pregnant women have been identified as a potentially at-risk group concerning COVID-19 infection, little is known regarding the susceptibility of the fetus to infection. Co-expression of ACE2 and TMPRSS2 has been identified as a pre-requisite for infection, and expression across different tissues is known to vary between children and adults. However, the expression of these proteins in the fetus is unknown. METHODS: We performed a retrospective analysis of a single cell data repository. The data were then validated at both gene and protein level by performing RT-qPCR and two-colour immunohistochemistry on a library of second-trimester human fetal tissues. FINDINGS: TMPRSS2 is present at both gene and protein level in the predominantly epithelial fetal tissues analysed. ACE2 is present at significant levels, only in the fetal intestine and kidney and is not expressed in the fetal lung. The placenta also does not co-express the two proteins across the second trimester or at term. INTERPRETATION: This dataset indicates that the lungs are unlikely to be a viable route of SARS-CoV2 fetal infection. The fetal kidney, despite presenting both the proteins required for the infection, is anatomically protected from the exposure to the virus. However, the GI tract is likely to be susceptible to infection due to its high co-expression of both proteins, as well as its exposure to potentially infected amniotic fluid.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherWiley
dc.relation.ispartofjournalBJOG: An International Journal of Obstetrics & Gynaecology
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchPaediatrics
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode3213
dc.subject.keywordsACE2
dc.subject.keywordsCOVID-19
dc.subject.keywordsFetal Infection
dc.subject.keywordsSARS-CoV2
dc.subject.keywordsTMPRSS2
dc.subject.keywordsvertical transmission
dc.titleCOVID-19 and vertical transmission: assessing the expression of ACE2 / TMPRSS2 in the human fetus and placenta to assess the risk of SARS-CoV-2 infection
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationBeesley, MA; Davidson, JR; Panariello, F; Shibuya, S; Scaglioni, D; Jones, BC; Maksym, K; Ogunbiyi, O; Sebire, NJ; Cacchiarelli, D; David, AL; De Coppi, P; Gerli, MFM, COVID-19 and vertical transmission: assessing the expression of ACE2 / TMPRSS2 in the human fetus and placenta to assess the risk of SARS-CoV-2 infection., BJOG: An International Journal of Obstetrics & Gynaecology, 2021
dc.date.updated2021-11-19T02:26:15Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2021 by the authors.BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd.This is an open access article under the terms of the Creative Commons Attribution License, which permits use,distribution and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorJones, Blake


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