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dc.contributor.authorCarlton, M
dc.contributor.authorVoisey, J
dc.contributor.authorParker, TJ
dc.contributor.authorPunyadeera, C
dc.contributor.authorCuttle, L
dc.date.accessioned2021-11-25T07:26:11Z
dc.date.available2021-11-25T07:26:11Z
dc.date.issued2021
dc.identifier.issn2321-3868en_US
dc.identifier.doi10.1093/burnst/tkaa049en_US
dc.identifier.urihttp://hdl.handle.net/10072/410355
dc.description.abstractBiological markers that evaluate physical healing as well as psychological impact of a burn are essential for effective treatment of paediatric burns. The objective of this review is to summarize the evidence supporting the use of biomarkers in children with burns. An extensive review of the literature was performed using PubMed. A total of 59 biomarkers were identified relating to burn presence, specifically relating to processes involved in inflammation, wound healing, growth and metabolism. In addition, biomarkers involved in the stress response cascade following a burn trauma were also identified. Although many biomarkers have been identified that are potentially associated with burn-related physical and psychological trauma, an understanding of burn biology is still lacking in children. We propose that future research in the field of children's burns should be conducted using broad screening methods for identifying potential biomarkers, examine the biological interactions of different biomarkers, utilize child-appropriate biological fluids such as urine or saliva, and include a range of different severity burns. Through further research, the biological response to burn injury may be fully realized and clinically relevant diagnostic tests and treatment therapies utilizing these biomarkers could be developed, for the improvement of healing outcomes in paediatric burn patients.en_US
dc.description.peerreviewedYesen_US
dc.languageengen_US
dc.publisherOxford University Press (OUP)en_US
dc.relation.ispartofjournalBurns and Traumaen_US
dc.relation.ispartofvolume9en_US
dc.subject.fieldofresearchPsychologyen_US
dc.subject.fieldofresearchClinical sciencesen_US
dc.subject.fieldofresearchPaediatricsen_US
dc.subject.fieldofresearchcode52en_US
dc.subject.fieldofresearchcode3202en_US
dc.subject.fieldofresearchcode3213en_US
dc.subject.keywordsBiomarkeren_US
dc.subject.keywordsHypothalamic-pituitary-adrenal axisen_US
dc.subject.keywordsInflammatoryen_US
dc.subject.keywordsPaediatric burnsen_US
dc.subject.keywordsPhysical traumaen_US
dc.titleA review of potential biomarkers for assessing physical and psychological trauma in paediatric burnsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationCarlton, M; Voisey, J; Parker, TJ; Punyadeera, C; Cuttle, L, A review of potential biomarkers for assessing physical and psychological trauma in paediatric burns, Burns and Trauma, 2021, 9en_US
dcterms.dateAccepted2021-01-03
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/en_US
dc.date.updated2021-11-23T22:42:13Z
dc.description.versionVersion of Record (VoR)en_US
gro.rights.copyright© The Author(s) 2021. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
gro.hasfulltextFull Text
gro.griffith.authorPunyadeera, Chamindie


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