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dc.contributor.authorWu, Yuao
dc.contributor.authorCowin, Gary
dc.contributor.authorMoonshi, Shehzahdi S
dc.contributor.authorTran, Huong DN
dc.contributor.authorFithri, Najma Annuria
dc.contributor.authorWhittaker, Andrew K
dc.contributor.authorZhang, Run
dc.contributor.authorTa, Hang T
dc.date.accessioned2021-11-25T07:51:01Z
dc.date.available2021-11-25T07:51:01Z
dc.date.issued2021
dc.identifier.issn0928-4931
dc.identifier.doi10.1016/j.msec.2021.112477
dc.identifier.urihttp://hdl.handle.net/10072/410361
dc.description.abstractIn this study, modular two-in-one nano-cocktails were synthesised to provide treatment of inflammatory diseases and also enable tracking of their delivery to the disease sites. Chitosan nano-cocktails loaded with treatment module (cerium oxide nanoparticles) and imaging module (iron oxide nanoparticles) were synthesised by electrostatic self-assembly (Chit-IOCO) and ionic gelation method (Chit-TPP-IOCO), respectively. Their MRI capability, anti-inflammatory and anti-fibrosis ability were investigated. Results demonstrated that Chit-IOCO significantly reduced the expression of TNF-α and COX-2, while Chit-TPP-IOCO reduced IL-6 in the LPS-stimulated macrophages RAW264.7. Cytotoxicity studies showed that the nano-cocktails inhibited the proliferation of macrophages. Additionally, Chit-IOCO exhibited higher in vitro MRI relaxivity than Chit-TPP-IOCO, indicating that Chit-IOCO is a better MRI contrast agent in macrophages. It was possible to track the delivery of Chit-IOCO to the inflamed livers of CCl4-treated C57BL/6 mice, demonstrated by a shortened T2⁎ relaxation time of the livers after injecting Chit-IOCO into mice. In vivo anti-inflammatory and blood tests demonstrated that Chit-IOCO reduced inflammation-related proteins (TNF-a, iNOS and Cox-2) and bilirubin in CCl4 treated C57BL/6. Histology images indicated that the nano-cocktails at the treatment doses did not affect the organs of the mice. Importantly, the nano-cocktail reduced fibrosis of CCl4-treated mouse liver. This is the first reported data on the anti-inflammation and anti-fibrosis efficacy of Chit-IOCO in C57BL/6 mouse liver inflammation model. Overall, Chit-IOCO nanoparticles have shown great potential in MR imaging/detecting and treating/therapeutic capabilities for inflammatory diseases.
dc.description.peerreviewedYes
dc.description.sponsorshipHeart Foundation of Australia
dc.languageEnglish
dc.publisherElsevier
dc.relation.ispartofpagefrom112477
dc.relation.ispartofjournalMaterials Science and Engineering: C
dc.relation.ispartofvolume131
dc.relation.urihttp://purl.org/au-research/grants/NHMRC/APP1146694
dc.relation.urihttp://purl.org/au-research/grants/NHMRC/APP2002827
dc.relation.grantIDAPP1146694
dc.relation.grantIDAPP2002827
dc.relation.fundersNHMRC
dc.subject.fieldofresearchBiomedical engineering
dc.subject.fieldofresearchMaterials engineering
dc.subject.fieldofresearchcode4003
dc.subject.fieldofresearchcode4016
dc.subject.keywordsScience & Technology
dc.subject.keywordsTechnology
dc.subject.keywordsMaterials Science, Biomaterials
dc.subject.keywordsMaterials Science
dc.subject.keywordsAnti-inflammatory
dc.titleEngineering chitosan nano-cocktail containing iron oxide and ceria: A two-in-one approach for treatment of inflammatory diseases and tracking of material delivery
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationWu, Y; Cowin, G; Moonshi, SS; Tran, HDN; Fithri, NA; Whittaker, AK; Zhang, R; Ta, HT, Engineering chitosan nano-cocktail containing iron oxide and ceria: A two-in-one approach for treatment of inflammatory diseases and tracking of material delivery, Materials Science and Engineering: C, 2021, 131, pp. 112477
dcterms.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.date.updated2021-11-15T23:30:06Z
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2021 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorMoonshi, Shehzahdi S.
gro.griffith.authorTa, Hang
gro.griffith.authorWu, Yuao
gro.griffith.authorTran, Huong
gro.griffith.authorFithri, Najma A.


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