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  • Ecology, evolution and spillover of coronaviruses from bats

    Author(s)
    Ruiz-Aravena, Manuel
    McKee, Clifton
    Gamble, Amandine
    Lunn, Tamika
    Morris, Aaron
    Snedden, Celine E
    Yinda, Claude Kwe
    Port, Julia R
    Buchholz, David W
    Yeo, Yao Yu
    Faust, Christina
    Jax, Elinor
    Dee, Lauren
    Jones, Devin N
    Kessler, Maureen K
    et al.
    Griffith University Author(s)
    Peel, Alison J.
    Lunn, Tamika J.
    Year published
    2021
    Metadata
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    Abstract
    In the past two decades, three coronaviruses with ancestral origins in bats have emerged and caused widespread outbreaks in humans, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since the first SARS epidemic in 2002-2003, the appreciation of bats as key hosts of zoonotic coronaviruses has advanced rapidly. More than 4,000 coronavirus sequences from 14 bat families have been identified, yet the true diversity of bat coronaviruses is probably much greater. Given that bats are the likely evolutionary source for several human coronaviruses, including strains that cause mild upper respiratory tract ...
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    In the past two decades, three coronaviruses with ancestral origins in bats have emerged and caused widespread outbreaks in humans, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since the first SARS epidemic in 2002-2003, the appreciation of bats as key hosts of zoonotic coronaviruses has advanced rapidly. More than 4,000 coronavirus sequences from 14 bat families have been identified, yet the true diversity of bat coronaviruses is probably much greater. Given that bats are the likely evolutionary source for several human coronaviruses, including strains that cause mild upper respiratory tract disease, their role in historic and future pandemics requires ongoing investigation. We review and integrate information on bat-coronavirus interactions at the molecular, tissue, host and population levels. We identify critical gaps in knowledge of bat coronaviruses, which relate to spillover and pandemic risk, including the pathways to zoonotic spillover, the infection dynamics within bat reservoir hosts, the role of prior adaptation in intermediate hosts for zoonotic transmission and the viral genotypes or traits that predict zoonotic capacity and pandemic potential. Filling these knowledge gaps may help prevent the next pandemic.
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    Journal Title
    Nature Reviews Microbiology
    DOI
    https://doi.org/10.1038/s41579-021-00652-2
    Subject
    Microbiology
    Medical microbiology
    bat–coronavirus interactions
    spillover
    pandemic
    Publication URI
    http://hdl.handle.net/10072/410393
    Collection
    • Journal articles

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