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  • The molecular dynamics of long noncoding RNA control of transcription in PTEN and its pseudogene

    Author(s)
    Lister, Nicholas
    Shevchenko, Galina
    Walshe, James L
    Groen, Jessica
    Johnsson, Per
    Vidarsdottir, Linda
    Grander, Dan
    Ataide, Sandro F
    Morris, Kevin V
    Griffith University Author(s)
    Morris, Kevin V.
    Year published
    2017
    Metadata
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    Abstract
    RNA has been found to interact with chromatin and modulate gene transcription. In human cells, little is known about how long noncoding RNAs (lncRNAs) interact with target loci in the context of chromatin. We find here, using the phosphatase and tensin homolog (PTEN) pseudogene as a model system, that antisense lncRNAs interact first with a 5′ UTR-containing promoter-spanning transcript, which is then followed by the recruitment of DNA methyltransferase 3a (DNMT3a), ultimately resulting in the transcriptional and epigenetic control of gene expression. Moreover, we find that the lncRNA and promoter-spanning transcript interaction ...
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    RNA has been found to interact with chromatin and modulate gene transcription. In human cells, little is known about how long noncoding RNAs (lncRNAs) interact with target loci in the context of chromatin. We find here, using the phosphatase and tensin homolog (PTEN) pseudogene as a model system, that antisense lncRNAs interact first with a 5′ UTR-containing promoter-spanning transcript, which is then followed by the recruitment of DNA methyltransferase 3a (DNMT3a), ultimately resulting in the transcriptional and epigenetic control of gene expression. Moreover, we find that the lncRNA and promoter-spanning transcript interaction are based on a combination of structural and sequence components of the antisense lncRNA. These observations suggest, on the basis of this one example, that evolutionary pressures may be placed on RNA structure more so than sequence conservation. Collectively, the observations presented here suggest a much more complex and vibrant RNA regulatory world may be operative in the regulation of gene expression.
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    Journal Title
    Proceedings of the National Academy of Sciences of the United States of America
    Volume
    114
    Issue
    37
    DOI
    https://doi.org/10.1073/pnas.1621490114
    Subject
    Genetics
    Science & Technology
    Multidisciplinary Sciences
    Science & Technology - Other Topics
    PTEN
    DNMT3a
    Publication URI
    http://hdl.handle.net/10072/410612
    Collection
    • Journal articles

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