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  • Study Protocol for a Randomized Controlled Trial of Choral Singing Intervention to Prevent Cognitive Decline in At-Risk Older Adults Living in the Community

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    Author(s)
    Tan, Jasmine
    Tsakok, FH Maurine
    Ow, Elisabeth K
    Lanskey, Bernard
    Lim, Kian Siong Darius
    Goh, Lee Gan
    Tan, Chay-Hoon
    Cheah, Irwin Kee-Mun
    Larbi, Anis
    Foo, Roger
    Loh, Marie
    Wong, Caroline Kai Yun
    Suckling, John
    Li, Jialiang
    Mahendran, Rathi
    et al.
    Griffith University Author(s)
    Lanskey, Bernard
    Year published
    2018
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    Abstract
    Introduction: This study is a parallel-arm randomized controlled trial evaluating choral singing’s efficacy and underlying mechanisms in preventing cognitive decline in at-risk older participants. Methods: Three-hundred and sixty community-dwelling, non-demented older participants are recruited for a 2-year intervention. Inclusion criteria are self-reported cognitive complaints, early cognitive impairment based on neuropsychological test scores or multiple risk factors of dementia. Participants are randomized to either weekly choral singing sessions or general health education. The primary outcome is cognitive performance, ...
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    Introduction: This study is a parallel-arm randomized controlled trial evaluating choral singing’s efficacy and underlying mechanisms in preventing cognitive decline in at-risk older participants. Methods: Three-hundred and sixty community-dwelling, non-demented older participants are recruited for a 2-year intervention. Inclusion criteria are self-reported cognitive complaints, early cognitive impairment based on neuropsychological test scores or multiple risk factors of dementia. Participants are randomized to either weekly choral singing sessions or general health education. The primary outcome is cognitive performance, measured by a composite cognitive test score (CCTS). Secondary outcomes include depression, anxiety and neuropsychiatric symptoms; perceived stress; sleep quality and severity of dementia symptoms. Underlying mechanisms are examined using blood- and urine-based biomarkers and neuroimaging. Results: Screening began in July 2016. The first group of participants (n = 93) have been recruited. Intervention and control treatments are ongoing and will end in December 2019. Discussion: An evidence-based singing intervention for dementia prevention holds potential for healthcare savings and societal welfare. Trial Registration: NCT02919748, IRB Approval Number: NUS 2508. Keywords: singing, cognitive decline, RCT, dementia prevention, neuroplasticity
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    Journal Title
    Frontiers in Aging Neuroscience
    Volume
    10
    DOI
    https://doi.org/10.3389/fnagi.2018.00195
    Copyright Statement
    © 2018 Tan, Tsakok, Ow, Lanskey, Lim, Goh, Tan, Cheah, Larbi, Foo, Loh, Wong, Suckling, Li, Mahendran, Kua and Feng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
    Subject
    Aged health care
    Music not elsewhere classified
    Neurosciences
    Publication URI
    http://hdl.handle.net/10072/410743
    Collection
    • Journal articles

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