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dc.contributor.authorLin, P
dc.contributor.authorMin, M
dc.contributor.authorLee, M
dc.contributor.authorHolloway, L
dc.contributor.authorForstner, D
dc.contributor.authorBray, V
dc.contributor.authorXuan, W
dc.contributor.authorChicco, A
dc.contributor.authorFowler, A
dc.date.accessioned2021-12-15T01:22:05Z
dc.date.available2021-12-15T01:22:05Z
dc.date.issued2016
dc.identifier.issn0167-8140
dc.identifier.doi10.1016/j.radonc.2016.05.021
dc.identifier.urihttp://hdl.handle.net/10072/410796
dc.description.abstractPurpose To evaluate the prognostic value of 18F-FDG-PET-CT performed prior to (prePET) and during the third week (iPET) of radiation therapy (RT) in nasopharyngeal carcinoma (NPC). Materials and methods Thirty-patients with newly diagnosed loco-regionally advanced NPC treated with radical RT underwent prePET and iPET. The median follow-up was 26 months (8–66.9). The maximum-standardised-uptake-value (SUVmax), metabolic-tumour-volume (MTV) and total-lesional-glycolysis (TLG) of the primary tumour (PT), index-node (IN) (lymph node with highest TLG), total-lymph-nodes (TN) and combined primary-tumour and nodal (PTN), and their % reductions in iPET were analysed, and results were correlated with 2-year Kaplan–Meier loco-recurrence-free-survival (LRFS), regional-failure-free-survival (RFFS), distant-metastatic-failure-free-survival (DMFFS), disease-free-survival (DFS), and overall-survival (OS). Optimal-cutoffs (OC) were derived from Receiver-Operating-Characteristic curves. Results For LRFS, the only predictor was reduction in PT MTV by >50%: 95.2% vs. 75.0%, p = 0.024. For other treatment outcomes, only nodal or PTN predicted outcomes. The IN SUVmax (pre-PET-OC = 10.45 g/mL and iPET-OC = 8.15) and TLG (prePET-OC = 90 g and iPET-OC = 33.4) were the best predictors of outcome: RFFS (iPET SUVmax/TLG): 100% vs. 50%, p < 0.001 and 100% vs. 44%, p = 0.032; DMFFS (prePET SUVmax/TLG); 100% vs. 51.9%, p = 0.004 and 100% vs. 47.6%, p = 0.002; DFS (prePET TLG and iPET SUVmax): 87.5% vs. 33%, p = 0.045 and 78.7% vs. 20%, p = 0.01; and OS (prePET TLG): 100% vs 66.3%, p = 0.036. Conclusions We have demonstrated IN of prePET and iPET to be a feasible and potentially useful novel imaging biomarker to predict for patients with NPC who have a high risk of regional or distant metastatic failure. Future work is required to validate our findings in a well-powered, prospective study with a standardised treatment protocol, and their potential use to guide individualised therapy for NPC.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherElsevier BV
dc.relation.ispartofpagefrom87
dc.relation.ispartofpageto91
dc.relation.ispartofissue1
dc.relation.ispartofjournalRadiotherapy and Oncology
dc.relation.ispartofvolume120
dc.subject.fieldofresearchOther physical sciences
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchMedical and biological physics
dc.subject.fieldofresearchcode5199
dc.subject.fieldofresearchcode3211
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode5105
dc.subject.keywordsAdaptive radiotherapy
dc.subject.keywordsFDG
dc.subject.keywordsImaging biomarker
dc.subject.keywordsNasopharyngeal carcinoma
dc.subject.keywordsPET CT
dc.titlePrognostic utility of 18F-FDG PET-CT performed prior to and during primary radiotherapy for nasopharyngeal carcinoma: Index node is a useful prognostic imaging biomarker site
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationLin, P; Min, M; Lee, M; Holloway, L; Forstner, D; Bray, V; Xuan, W; Chicco, A; Fowler, A, Prognostic utility of 18F-FDG PET-CT performed prior to and during primary radiotherapy for nasopharyngeal carcinoma: Index node is a useful prognostic imaging biomarker site, Radiotherapy and Oncology, 2016, 120 (1), pp. 87-91
dcterms.dateAccepted2016-05-20
dc.date.updated2021-12-15T01:20:49Z
gro.hasfulltextNo Full Text
gro.griffith.authorMin, Myo


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