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dc.contributor.authorGonzález García, Laura E
dc.contributor.authorNinan, Neethu
dc.contributor.authorSimon, Johanna
dc.contributor.authorMadathiparambil Visalakshan, Rahul
dc.contributor.authorBright, Richard
dc.contributor.authorWahono, Satriyo K
dc.contributor.authorOstrikov, Kostya
dc.contributor.authorMailänder, Volker
dc.contributor.authorLandfester, Katharina
dc.contributor.authorGoswami, Nirmal
dc.contributor.authorVasilev, Krasimir
dc.date.accessioned2021-12-16T03:50:31Z
dc.date.available2021-12-16T03:50:31Z
dc.date.issued2021
dc.identifier.issn2040-3364
dc.identifier.doi10.1039/d1nr06591b
dc.identifier.urihttp://hdl.handle.net/10072/410907
dc.description.abstractHemostatic agents are pivotal for managing clinical and traumatic bleeding during emergency and domestic circumstances. Herein, a novel functional hybrid nanocomposite material consisting of plasma polymer-modified zeolite 13X and ultra-small gold nanoclusters (AuNCs) was fabricated as an efficient hemostatic agent. The surface of zeolite 13X was functionalised with amine groups which served as binding sites for carboxylate terminated AuNCs. Protein corona studies revealed the enhanced adsorption of two proteins, namely, coagulation factors and plasminogen as a result of AuNCs immobilization on the zeolite surface. The immune response studies showed that the hybrid nanocomposites are effective in reducing inflammation, which combined with a greater attachment of vitronectin, may promote wound healing. The hemostatic potential of the nanocomposite could be directly correlated with their immunomodulatory and anti-haemorrhagic properties. Together, the hybrid nanoengineered material developed in this work could provide a new avenue to tackle life-threatening injuries in civilian and other emergencies.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherRoyal Society of Chemistry (RSC)
dc.relation.ispartofpagefrom19936
dc.relation.ispartofpageto19945
dc.relation.ispartofjournalNanoscale
dc.relation.ispartofvolume13
dc.subject.fieldofresearchAnalytical chemistry
dc.subject.fieldofresearchMacromolecular and materials chemistry
dc.subject.fieldofresearchcode3401
dc.subject.fieldofresearchcode3403
dc.titleUltra-small gold nanoclusters assembled on plasma polymer-modified zeolites: a multifunctional nanohybrid with anti-haemorrhagic and anti-inflammatory properties
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationGonzález García, LE; Ninan, N; Simon, J; Madathiparambil Visalakshan, R; Bright, R; Wahono, SK; Ostrikov, K; Mailänder, V; Landfester, K; Goswami, N; Vasilev, K, Ultra-small gold nanoclusters assembled on plasma polymer-modified zeolites: a multifunctional nanohybrid with anti-haemorrhagic and anti-inflammatory properties., Nanoscale, 2021, 13, pp. 19936-19945
dc.date.updated2021-12-03T01:03:36Z
gro.hasfulltextNo Full Text
gro.griffith.authorOstrikov, Ken


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