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  • MP-AzeFlu in Moderate-to-Severe Allergic Rhinitis: A Literature Review

    Author(s)
    Klimek, L
    Berger, WE
    Bousquet, J
    Keith, PK
    Smith, P
    Sole, D
    Scadding, G
    Kuhl, HC
    Nguyen, DT
    Kopietz, F
    Koltun, A
    Griffith University Author(s)
    Smith, Peter K.
    Year published
    2021
    Metadata
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    Abstract
    Allergic rhinitis (AR) is prevalent, and many patients present with moderate-to-severe symptomatic disease. The majority of patients are not satisfied with their AR treatment, despite the use of concurrent medications. These gaps underscore the need for treatment with more effective options for moderate-to-severe AR. The authors' objective was to review systematically the efficacy and safety of MP-AzeFlu for the treatment of AR. The primary outcomes studied were nasal, ocular, and total symptoms. Other outcomes included time to onset and of AR control, quality of life, and safety. Searches of PubMed and Cochrane databases ...
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    Allergic rhinitis (AR) is prevalent, and many patients present with moderate-to-severe symptomatic disease. The majority of patients are not satisfied with their AR treatment, despite the use of concurrent medications. These gaps underscore the need for treatment with more effective options for moderate-to-severe AR. The authors' objective was to review systematically the efficacy and safety of MP-AzeFlu for the treatment of AR. The primary outcomes studied were nasal, ocular, and total symptoms. Other outcomes included time to onset and of AR control, quality of life, and safety. Searches of PubMed and Cochrane databases were conducted on May 14, 2020, with no date restrictions, to identify publications reporting data on MP-AzeFlu. Clinical studies of any phase were included. Studies were excluded if they were not in English, were review articles, did not discuss the safety and efficacy of MP-AzeFlu for AR symptoms. Treatment of AR with MP-AzeFlu results in effective, sustained relief of nasal and ocular symptoms, and faster onset and time to control compared with intranasal azelastine or fluticasone propionate. Long-term use of MP-AzeFlu was safe, with benefits in children, adults, and adults aged ≥65 years. Other treatment options, including fluticasone propionate and azelastine alone or the combination of intranasal corticosteroids and oral antihistamine, do not provide the same level of efficacy as MP-AzeFlu in terms of rapid and sustained relief of the entire AR symptom complex. Furthermore, MP-AzeFlu significantly improves patient quality of life. MP-AzeFlu is a currently available combination that may satisfy all these patient needs and expectations.
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    Journal Title
    International Archives of Allergy and Immunology
    Volume
    182
    Issue
    11
    DOI
    https://doi.org/10.1159/000516417
    Subject
    Immunology
    Allergic rhinitis
    Azelastine
    Fluticasone propionate
    MP-AzeFlu
    Nasal symptoms
    Publication URI
    http://hdl.handle.net/10072/410951
    Collection
    • Journal articles

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