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dc.contributor.authorMaity, S
dc.contributor.authorKinra, M
dc.contributor.authorNampoothiri, M
dc.contributor.authorArora, D
dc.contributor.authorPai, KSR
dc.contributor.authorMudgal, J
dc.date.accessioned2021-12-17T03:43:58Z
dc.date.available2021-12-17T03:43:58Z
dc.date.issued2021
dc.identifier.issn0366-6352
dc.identifier.doi10.1007/s11696-021-01947-7
dc.identifier.urihttp://hdl.handle.net/10072/411014
dc.description.abstractIncreased effectiveness and decreasing toxicity are prime objectives in drug research. Overwhelming evidence suggests the use of appropriate combination therapy for the better efficacy of drugs owing to their synergistic profile. Dietary active constituents play a major role in health outcomes. Therefore, it is possible to increase the effectiveness of the drug by combining contemporary medication with active natural/semi-synthetic constituents. One such dietary constituent, caffeic acid (CA), is a by-product of the shikimate pathway in plants and is a polyphenol of hydroxycinnamic acid class. Extensive research on CA has proposed its efficacy against inflammatory, neurodegenerative, oncologic, and metabolic disorders. The synergistic/additive effects of CA in combination with drugs like caffeine, metformin, pioglitazone, and quercetin have been reported in several experimental models and thus the present review is an attempt to consolidate outcomes of this research. Multi-target-based mechanistic studies will facilitate the development of effective combination regimens of CA.
dc.description.peerreviewedYes
dc.languageen
dc.publisherSpringer Science and Business Media LLC
dc.relation.ispartofjournalChemical Papers
dc.subject.fieldofresearchChemical sciences
dc.subject.fieldofresearchcode34
dc.titleCaffeic acid, a dietary polyphenol, as a promising candidate for combination therapy
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationMaity, S; Kinra, M; Nampoothiri, M; Arora, D; Pai, KSR; Mudgal, J, Caffeic acid, a dietary polyphenol, as a promising candidate for combination therapy, Chemical Papers, 2021
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2021-12-17T01:48:02Z
dc.description.versionVersion of Record (VoR)
gro.description.notepublicThis publication has been entered in Griffith Research Online as an advanced online version.
gro.rights.copyright© The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.
gro.hasfulltextFull Text
gro.griffith.authorArora, Devinder S.


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