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  • Routine first trimester combined screening for preterm preeclampsia in Australia: a multicenter clinical implementation cohort study.

    Author(s)
    Rolnik, Daniel L
    Selvaratnam, Roshan J
    Wertaschnigg, Dagmar
    Meagher, Simon
    Wallace, Euan
    Hyett, Jon
    da Silva Costa, Fabricio
    McLennan, Andrew
    Griffith University Author(s)
    Da Silva Costa, Fabricio
    Year published
    2021
    Metadata
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    Abstract
    OBJECTIVE: To assess pregnancy outcomes following first trimester combined screening for preterm preeclampsia in Australia. METHODS: We compared pregnancy outcomes of women with singleton pregnancies who underwent first trimester combined preeclampsia screening with the Fetal Medicine Foundation algorithm between 2014 and 2017 in Melbourne and Sydney, Australia, with those from women who received standard care. The primary outcomes were preterm preeclampsia and screening performance. Effect estimates were presented as risk ratios with 95% confidence intervals. RESULTS: A total of 29,618 women underwent combined screening and ...
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    OBJECTIVE: To assess pregnancy outcomes following first trimester combined screening for preterm preeclampsia in Australia. METHODS: We compared pregnancy outcomes of women with singleton pregnancies who underwent first trimester combined preeclampsia screening with the Fetal Medicine Foundation algorithm between 2014 and 2017 in Melbourne and Sydney, Australia, with those from women who received standard care. The primary outcomes were preterm preeclampsia and screening performance. Effect estimates were presented as risk ratios with 95% confidence intervals. RESULTS: A total of 29,618 women underwent combined screening and 301,566 women received standard care. Women who had combined screening were less likely to have preeclampsia, preterm birth, small neonates, and low Apgar scores than the general population. Women with high-risk results (≥ 1 in 100) were more likely to develop preterm preeclampsia (2.1% versus 0.7%, risk ratio [RR] 3.04, 95% CI 2.46-3.77), while low-risk women (risk < 1 in 100) had lower rates of preterm preeclampsia (0.2% versus 0.7%, RR 0.26, 95% CI 0.19-0.35) and other pregnancy complications. CONCLUSIONS: First trimester screening for preeclampsia in clinical practice identified a population at high risk of adverse pregnancy outcomes and low-risk women who may be suitable for less intensive antenatal care.
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    Journal Title
    International Journal of Gynecology & Obstetrics
    DOI
    https://doi.org/10.1002/ijgo.14049
    Note
    This publication has been entered in Griffith Research Online as an advanced online version.
    Subject
    Paediatrics
    Aspirin
    Biomarkers
    First trimester combined screening
    Prediction
    Preeclampsia
    Publication URI
    http://hdl.handle.net/10072/411037
    Collection
    • Journal articles

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