Routine first trimester combined screening for preterm preeclampsia in Australia: a multicenter clinical implementation cohort study.
Author(s)
Rolnik, Daniel L
Selvaratnam, Roshan J
Wertaschnigg, Dagmar
Meagher, Simon
Wallace, Euan
Hyett, Jon
da Silva Costa, Fabricio
McLennan, Andrew
Griffith University Author(s)
Year published
2021
Metadata
Show full item recordAbstract
OBJECTIVE: To assess pregnancy outcomes following first trimester combined screening for preterm preeclampsia in Australia. METHODS: We compared pregnancy outcomes of women with singleton pregnancies who underwent first trimester combined preeclampsia screening with the Fetal Medicine Foundation algorithm between 2014 and 2017 in Melbourne and Sydney, Australia, with those from women who received standard care. The primary outcomes were preterm preeclampsia and screening performance. Effect estimates were presented as risk ratios with 95% confidence intervals. RESULTS: A total of 29,618 women underwent combined screening and ...
View more >OBJECTIVE: To assess pregnancy outcomes following first trimester combined screening for preterm preeclampsia in Australia. METHODS: We compared pregnancy outcomes of women with singleton pregnancies who underwent first trimester combined preeclampsia screening with the Fetal Medicine Foundation algorithm between 2014 and 2017 in Melbourne and Sydney, Australia, with those from women who received standard care. The primary outcomes were preterm preeclampsia and screening performance. Effect estimates were presented as risk ratios with 95% confidence intervals. RESULTS: A total of 29,618 women underwent combined screening and 301,566 women received standard care. Women who had combined screening were less likely to have preeclampsia, preterm birth, small neonates, and low Apgar scores than the general population. Women with high-risk results (≥ 1 in 100) were more likely to develop preterm preeclampsia (2.1% versus 0.7%, risk ratio [RR] 3.04, 95% CI 2.46-3.77), while low-risk women (risk < 1 in 100) had lower rates of preterm preeclampsia (0.2% versus 0.7%, RR 0.26, 95% CI 0.19-0.35) and other pregnancy complications. CONCLUSIONS: First trimester screening for preeclampsia in clinical practice identified a population at high risk of adverse pregnancy outcomes and low-risk women who may be suitable for less intensive antenatal care.
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View more >OBJECTIVE: To assess pregnancy outcomes following first trimester combined screening for preterm preeclampsia in Australia. METHODS: We compared pregnancy outcomes of women with singleton pregnancies who underwent first trimester combined preeclampsia screening with the Fetal Medicine Foundation algorithm between 2014 and 2017 in Melbourne and Sydney, Australia, with those from women who received standard care. The primary outcomes were preterm preeclampsia and screening performance. Effect estimates were presented as risk ratios with 95% confidence intervals. RESULTS: A total of 29,618 women underwent combined screening and 301,566 women received standard care. Women who had combined screening were less likely to have preeclampsia, preterm birth, small neonates, and low Apgar scores than the general population. Women with high-risk results (≥ 1 in 100) were more likely to develop preterm preeclampsia (2.1% versus 0.7%, risk ratio [RR] 3.04, 95% CI 2.46-3.77), while low-risk women (risk < 1 in 100) had lower rates of preterm preeclampsia (0.2% versus 0.7%, RR 0.26, 95% CI 0.19-0.35) and other pregnancy complications. CONCLUSIONS: First trimester screening for preeclampsia in clinical practice identified a population at high risk of adverse pregnancy outcomes and low-risk women who may be suitable for less intensive antenatal care.
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Journal Title
International Journal of Gynecology & Obstetrics
Note
This publication has been entered in Griffith Research Online as an advanced online version.
Subject
Paediatrics
Aspirin
Biomarkers
First trimester combined screening
Prediction
Preeclampsia