Show simple item record

dc.contributor.authorRolnik, Daniel L
dc.contributor.authorSelvaratnam, Roshan J
dc.contributor.authorWertaschnigg, Dagmar
dc.contributor.authorMeagher, Simon
dc.contributor.authorWallace, Euan
dc.contributor.authorHyett, Jon
dc.contributor.authorda Silva Costa, Fabricio
dc.contributor.authorMcLennan, Andrew
dc.description.abstractOBJECTIVE: To assess pregnancy outcomes following first trimester combined screening for preterm preeclampsia in Australia. METHODS: We compared pregnancy outcomes of women with singleton pregnancies who underwent first trimester combined preeclampsia screening with the Fetal Medicine Foundation algorithm between 2014 and 2017 in Melbourne and Sydney, Australia, with those from women who received standard care. The primary outcomes were preterm preeclampsia and screening performance. Effect estimates were presented as risk ratios with 95% confidence intervals. RESULTS: A total of 29,618 women underwent combined screening and 301,566 women received standard care. Women who had combined screening were less likely to have preeclampsia, preterm birth, small neonates, and low Apgar scores than the general population. Women with high-risk results (≥ 1 in 100) were more likely to develop preterm preeclampsia (2.1% versus 0.7%, risk ratio [RR] 3.04, 95% CI 2.46-3.77), while low-risk women (risk < 1 in 100) had lower rates of preterm preeclampsia (0.2% versus 0.7%, RR 0.26, 95% CI 0.19-0.35) and other pregnancy complications. CONCLUSIONS: First trimester screening for preeclampsia in clinical practice identified a population at high risk of adverse pregnancy outcomes and low-risk women who may be suitable for less intensive antenatal care.
dc.relation.ispartofjournalInternational Journal of Gynecology & Obstetrics
dc.subject.keywordsFirst trimester combined screening
dc.titleRoutine first trimester combined screening for preterm preeclampsia in Australia: a multicenter clinical implementation cohort study.
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationRolnik, DL; Selvaratnam, RJ; Wertaschnigg, D; Meagher, S; Wallace, E; Hyett, J; da Silva Costa, F; McLennan, A, Routine first trimester combined screening for preterm preeclampsia in Australia: a multicenter clinical implementation cohort study, International Journal of Gynecology & Obstetrics, 2021
gro.description.notepublicThis publication has been entered in Griffith Research Online as an advanced online version.
gro.hasfulltextNo Full Text
gro.griffith.authorDa Silva Costa, Fabricio

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record