Discovery of tanshinone derivatives with anti-MRSA activity via targeted bio-transformation
Author(s)
He, Wenni
Liu, Miaomiao
Huang, Pei
Abdel-Mageed, Wael M
Han, Jianying
Watrous, Jeramie D
Nguyen, Don D
Wang, Wenzhao
Song, Fuhang
Dai, Huanqin
Zhang, Jingyu
Quinn, Ronald J
Grkovi, Tanja
Luo, Houwei
Zhang, Lixin
et al.
Year published
2016
Metadata
Show full item recordAbstract
Two potent anti-MRSA tanshinone glycosides (1 and 2) were discovered by targeted microbial biotransformation, along with rapid identification via MS/MS networking. Serial reactions including dehydrogenation, demethylations, reduction, glycosylation and methylation have been observed after incubation of tanshinone IIA and fungus Mucor rouxianus AS 3.3447. In addition, tanshinosides B (2) showed potent activities against serial clinical isolates of oxacillin-resistant Staphylococcus aureus with MIC values of 0.78 μg/mL. This is the first study that shows a significant increase in the level and activities of tanshinone glycosides ...
View more >Two potent anti-MRSA tanshinone glycosides (1 and 2) were discovered by targeted microbial biotransformation, along with rapid identification via MS/MS networking. Serial reactions including dehydrogenation, demethylations, reduction, glycosylation and methylation have been observed after incubation of tanshinone IIA and fungus Mucor rouxianus AS 3.3447. In addition, tanshinosides B (2) showed potent activities against serial clinical isolates of oxacillin-resistant Staphylococcus aureus with MIC values of 0.78 μg/mL. This is the first study that shows a significant increase in the level and activities of tanshinone glycosides relative to the substrate tanshinone IIA.
View less >
View more >Two potent anti-MRSA tanshinone glycosides (1 and 2) were discovered by targeted microbial biotransformation, along with rapid identification via MS/MS networking. Serial reactions including dehydrogenation, demethylations, reduction, glycosylation and methylation have been observed after incubation of tanshinone IIA and fungus Mucor rouxianus AS 3.3447. In addition, tanshinosides B (2) showed potent activities against serial clinical isolates of oxacillin-resistant Staphylococcus aureus with MIC values of 0.78 μg/mL. This is the first study that shows a significant increase in the level and activities of tanshinone glycosides relative to the substrate tanshinone IIA.
View less >
Journal Title
Synthetic and Systems Biotechnology
Volume
1
Issue
3
Subject
Microbiology
Nanobiotechnology
Science & Technology
Life Sciences & Biomedicine
Biotechnology & Applied Microbiology
Biotransformation
Glycosylation