• myGriffith
    • Staff portal
    • Contact Us⌄
      • Future student enquiries 1800 677 728
      • Current student enquiries 1800 154 055
      • International enquiries +61 7 3735 6425
      • General enquiries 07 3735 7111
      • Online enquiries
      • Staff phonebook
    View Item 
    •   Home
    • Griffith Research Online
    • Journal articles
    • View Item
    • Home
    • Griffith Research Online
    • Journal articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

  • All of Griffith Research Online
    • Communities & Collections
    • Authors
    • By Issue Date
    • Titles
  • This Collection
    • Authors
    • By Issue Date
    • Titles
  • Statistics

  • Most Popular Items
  • Statistics by Country
  • Most Popular Authors
  • Support

  • Contact us
  • FAQs
  • Admin login

  • Login
  • Discovery of tanshinone derivatives with anti-MRSA activity via targeted bio-transformation

    Author(s)
    He, Wenni
    Liu, Miaomiao
    Huang, Pei
    Abdel-Mageed, Wael M
    Han, Jianying
    Watrous, Jeramie D
    Nguyen, Don D
    Wang, Wenzhao
    Song, Fuhang
    Dai, Huanqin
    Zhang, Jingyu
    Quinn, Ronald J
    Grkovi, Tanja
    Luo, Houwei
    Zhang, Lixin
    et al.
    Griffith University Author(s)
    Quinn, Ronald J.
    Liu, Miaomiao
    Year published
    2016
    Metadata
    Show full item record
    Abstract
    Two potent anti-MRSA tanshinone glycosides (1 and 2) were discovered by targeted microbial biotransformation, along with rapid identification via MS/MS networking. Serial reactions including dehydrogenation, demethylations, reduction, glycosylation and methylation have been observed after incubation of tanshinone IIA and fungus Mucor rouxianus AS 3.3447. In addition, tanshinosides B (2) showed potent activities against serial clinical isolates of oxacillin-resistant Staphylococcus aureus with MIC values of 0.78 μg/mL. This is the first study that shows a significant increase in the level and activities of tanshinone glycosides ...
    View more >
    Two potent anti-MRSA tanshinone glycosides (1 and 2) were discovered by targeted microbial biotransformation, along with rapid identification via MS/MS networking. Serial reactions including dehydrogenation, demethylations, reduction, glycosylation and methylation have been observed after incubation of tanshinone IIA and fungus Mucor rouxianus AS 3.3447. In addition, tanshinosides B (2) showed potent activities against serial clinical isolates of oxacillin-resistant Staphylococcus aureus with MIC values of 0.78 μg/mL. This is the first study that shows a significant increase in the level and activities of tanshinone glycosides relative to the substrate tanshinone IIA.
    View less >
    Journal Title
    Synthetic and Systems Biotechnology
    Volume
    1
    Issue
    3
    DOI
    https://doi.org/10.1016/j.synbio.2016.05.002
    Subject
    Microbiology
    Nanobiotechnology
    Science & Technology
    Life Sciences & Biomedicine
    Biotechnology & Applied Microbiology
    Biotransformation
    Glycosylation
    Publication URI
    http://hdl.handle.net/10072/411049
    Collection
    • Journal articles

    Footer

    Disclaimer

    • Privacy policy
    • Copyright matters
    • CRICOS Provider - 00233E
    • TEQSA: PRV12076

    Tagline

    • Gold Coast
    • Logan
    • Brisbane - Queensland, Australia
    First Peoples of Australia
    • Aboriginal
    • Torres Strait Islander