dc.contributor.author | Goyal, Vikas | |
dc.contributor.author | Grimwood, Keith | |
dc.contributor.author | Ware, Robert S | |
dc.contributor.author | Byrnes, Catherine | |
dc.contributor.author | Morris, Peter S | |
dc.contributor.author | Masters, I Brent | |
dc.contributor.author | McCallum, Gabrielle B | |
dc.contributor.author | Binks, Michael J | |
dc.contributor.author | Smith-Vaughan, Heidi | |
dc.contributor.author | O’Grady, Kerry-Ann F | |
dc.contributor.author | Champion, Anita | |
dc.contributor.author | Buntain, Helen M | |
dc.contributor.author | Schultz, Andr eacute | |
dc.contributor.author | Chatfield, Mark | |
dc.contributor.author | Torzillo, Paul J | |
dc.contributor.author | et al. | |
dc.date.accessioned | 2021-12-20T03:51:54Z | |
dc.date.available | 2021-12-20T03:51:54Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 0140-6736 | |
dc.identifier.uri | http://hdl.handle.net/10072/411065 | |
dc.description.abstract | Background: Bronchiectasis guidelines recommend antibiotics for treating acute respiratory exacerbations, but placebo-controlled, randomised-controlled trials (RCTs) are lacking in children. Since many exacerbations are virus-triggered, antibiotics may be unnecessary for non-severe (non-hospitalised) episodes. We hypothesised that oral amoxicillin-clavulanate and azithromycin are both superior to placebo for achieving symptom resolution by day-14 when treating non-severe exacerbations in children. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.publisher | The Lancet Publishing Group | |
dc.publisher.place | United Kingdom | |
dc.publisher.uri | https://www.thelancet.com/ | |
dc.relation.ispartofissue | 9 | |
dc.relation.ispartofjournal | The Lancet | |
dc.subject.fieldofresearch | Biomedical and clinical sciences | |
dc.subject.fieldofresearch | Clinical sciences | |
dc.subject.fieldofresearch | Health sciences | |
dc.subject.fieldofresearchcode | 32 | |
dc.subject.fieldofresearchcode | 3202 | |
dc.subject.fieldofresearchcode | 42 | |
dc.title | Efficacy of Oral Antibiotics for Non-Severe Exacerbations of Bronchiectasis in Children (BEST 1): A Multi-Centre, Double-Blind, Double-Dummy, Randomised Placebo-Controlled Trial | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dcterms.bibliographicCitation | Goyal, V; Grimwood, K; Ware, RS; Byrnes, C; Morris, PS; Masters, IB; McCallum, GB; Binks, MJ; Smith-Vaughan, H; O’Grady, K-AF; Champion, A; Buntain, HM; Schultz, AE; Chatfield, M; Torzillo, PJ; Chang, AB, Efficacy of Oral Antibiotics for Non-Severe Exacerbations of Bronchiectasis in Children (BEST 1): A Multi-Centre, Double-Blind, Double-Dummy, Randomised Placebo-Controlled Trial, The Lancet, 2019, (9) | |
dc.date.updated | 2021-12-20T03:45:08Z | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Grimwood, Keith | |
gro.griffith.author | Ware, Robert | |