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  • Angiogenesis-osteogenesis coupling: a key element in bone physiology and regeneration

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    Author(s)
    Boston, Bridget
    Ipe, Deepak
    Capitanescu, Bogdan
    Hamlet, Stephen
    Love, Robert
    Nusem, Iulian
    Miroiu, Rodica Ileana
    Warnke, Patrick Hans-Heinrich
    Petcu, Eugen Bogdan
    Griffith University Author(s)
    Love, Robert M.
    Hamlet, Stephen
    Year published
    2021
    Metadata
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    Abstract
    Bone represents a well vascularized structure which is remodelled and renewed continuously. It consists of osteoblasts, osteoclasts and osteocytes which have a precise role in the context of endochondral and intramembranous ossification. While the link between the bone tissue, bone marrow and the haematopoiesis is crucial for the generation of progenitor bone forming cells, recent research indicates that bone physiology as well as bone healing, repair and regeneration is directly dependent on bone angiogenesis. Experimental research suggest that angiogenesis and osteogenesis are directly coupled through a mechanism in which ...
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    Bone represents a well vascularized structure which is remodelled and renewed continuously. It consists of osteoblasts, osteoclasts and osteocytes which have a precise role in the context of endochondral and intramembranous ossification. While the link between the bone tissue, bone marrow and the haematopoiesis is crucial for the generation of progenitor bone forming cells, recent research indicates that bone physiology as well as bone healing, repair and regeneration is directly dependent on bone angiogenesis. Experimental research suggest that angiogenesis and osteogenesis are directly coupled through a mechanism in which type H endothelial cells have a role of paramount importance. Apart from type H endothelial cells, other molecular elements such as HIF and Notch as well as CD31-endomucin capillaries and miR-497∼195 endothelial clusters may have a significant role in angiogenesis-osteogenesis coupling. The number of type H endothelial cells decreases significantly in elderly and is paralleled by a significant drop in the supply of progenitor cells. This would explain the bone loss and the decreased bone regeneration potential seen in elderly patients. Overall, it is suggested that endothelial cells and bone angiogenesis would represent therapeutic targets in various pathological conditions characterized by bone loss and impaired regeneration.
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    Journal Title
    Vascular Cell
    Volume
    13
    Issue
    1
    DOI
    https://doi.org/10.24238/13221-13-1-203
    Copyright Statement
    © 2021 Bridget Boston, Deepak Ipe, Bogdan Capitanescu, Stephen Hamlet, Robert Love, Iulian Nusem, Rodica Ileana Miroiu, Patrick Hans-Heinrich Warnke, Eugen Bogdan Petcu. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (https://creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
    Subject
    Biochemistry and cell biology
    Cardiovascular medicine and haematology
    Oncology and carcinogenesis
    Publication URI
    http://hdl.handle.net/10072/411222
    Collection
    • Journal articles

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