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dc.contributor.authorBoston, Bridget
dc.contributor.authorIpe, Deepak
dc.contributor.authorCapitanescu, Bogdan
dc.contributor.authorHamlet, Stephen
dc.contributor.authorLove, Robert
dc.contributor.authorNusem, Iulian
dc.contributor.authorMiroiu, Rodica Ileana
dc.contributor.authorWarnke, Patrick Hans-Heinrich
dc.contributor.authorPetcu, Eugen Bogdan
dc.date.accessioned2021-12-22T04:17:13Z
dc.date.available2021-12-22T04:17:13Z
dc.date.issued2021
dc.identifier.issn2045-824X
dc.identifier.doi10.24238/13221-13-1-203
dc.identifier.urihttp://hdl.handle.net/10072/411222
dc.description.abstractBone represents a well vascularized structure which is remodelled and renewed continuously. It consists of osteoblasts, osteoclasts and osteocytes which have a precise role in the context of endochondral and intramembranous ossification. While the link between the bone tissue, bone marrow and the haematopoiesis is crucial for the generation of progenitor bone forming cells, recent research indicates that bone physiology as well as bone healing, repair and regeneration is directly dependent on bone angiogenesis. Experimental research suggest that angiogenesis and osteogenesis are directly coupled through a mechanism in which type H endothelial cells have a role of paramount importance. Apart from type H endothelial cells, other molecular elements such as HIF and Notch as well as CD31-endomucin capillaries and miR-497∼195 endothelial clusters may have a significant role in angiogenesis-osteogenesis coupling. The number of type H endothelial cells decreases significantly in elderly and is paralleled by a significant drop in the supply of progenitor cells. This would explain the bone loss and the decreased bone regeneration potential seen in elderly patients. Overall, it is suggested that endothelial cells and bone angiogenesis would represent therapeutic targets in various pathological conditions characterized by bone loss and impaired regeneration.
dc.description.peerreviewedYes
dc.languageen
dc.publisherPubliverse Online S.R.L
dc.relation.ispartofpagefrom2
dc.relation.ispartofissue1
dc.relation.ispartofjournalVascular Cell
dc.relation.ispartofvolume13
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchCardiovascular medicine and haematology
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchBioinformatics and computational biology
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode3201
dc.subject.fieldofresearchcode3211
dc.subject.fieldofresearchcode3102
dc.titleAngiogenesis-osteogenesis coupling: a key element in bone physiology and regeneration
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationBoston, B; Ipe, D; Capitanescu, B; Hamlet, S; Love, R; Nusem, I; Miroiu, RI; Warnke, PH-H; Petcu, EB, Angiogenesis-osteogenesis coupling: a key element in bone physiology and regeneration, Vascular Cell, 13 (1), pp. 2
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2021-12-21T00:16:55Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2021 Bridget Boston, Deepak Ipe, Bogdan Capitanescu, Stephen Hamlet, Robert Love, Iulian Nusem, Rodica Ileana Miroiu, Patrick Hans-Heinrich Warnke, Eugen Bogdan Petcu. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (https://creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
gro.hasfulltextFull Text
gro.griffith.authorHamlet, Stephen


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