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dc.contributor.authorKinra, M
dc.contributor.authorNampoothiri, M
dc.contributor.authorArora, D
dc.contributor.authorMudgal, J
dc.description.abstractCells encounter continuous challenges due to tissue insult caused by endogenous and/or exogenous stimuli. Among the mechanisms set in place to counterbalance the tissue insult, innate immunity is always at the forefront. Cells of innate immunity efficiently recognize the ‘danger signals’ via a specialized set of membrane-bound receptors known as Toll-like receptors. Once this interaction is established, toll-like receptor passes on the responsibility to cytosolic NOD-like receptors through a cascade of signalling pathways. Subsequently, NOD-like receptors assemble to a specialized multiprotein intracellular complex, that is inflammasome. Inflammasome activates Caspase-1 and Gasdermin-D which initiate pyroptotic cell death in the affected tissue by two simultaneous mechanisms. Being a protease, caspase-1 cleaves and activates pro-inflammatory cytokines IL-1β and IL-18. On the other hand, Gasdermin-D causes proteolytic cleavage which forms a pore in the cell membrane. This review highlights the molecular events ranging from recognition of stimuli to pyroptosis. The review is also an attempt to discuss the mechanisms of the most specific experimental NLRP3 inhibitors.
dc.relation.ispartofjournalScandinavian Journal of Immunology
dc.subject.fieldofresearchClinical sciences
dc.subject.keywordsNLRP3 inhibitors
dc.subject.keywordsinnate immune system
dc.subject.keywordspathogen-associated molecular patterns (PAMPs)
dc.subject.keywordsdanger-associated molecular patterns (DAMPs)
dc.titleReviewing the importance of TLR-NLRP3-pyroptosis pathway and mechanism of experimental NLRP3 inflammasome inhibitors
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationKinra, M; Nampoothiri, M; Arora, D; Mudgal, J, Reviewing the importance of TLR-NLRP3-pyroptosis pathway and mechanism of experimental NLRP3 inflammasome inhibitors, Scandinavian Journal of Immunology, 2021
gro.description.notepublicThis publication has been entered in Griffith Research Online as an advanced online version.
gro.hasfulltextNo Full Text
gro.griffith.authorArora, Devinder S.

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