Show simple item record

dc.contributor.authorNash, Peter
dc.contributor.authorMease, Philip J
dc.contributor.authorKirkham, Bruce
dc.contributor.authorSinghal, Atul
dc.contributor.authorQuebe-Fehling, Erhard
dc.contributor.authorPricop, Luminita
dc.contributor.authorGaillez, Corine
dc.date.accessioned2022-01-06T02:55:07Z
dc.date.available2022-01-06T02:55:07Z
dc.date.issued2022
dc.identifier.issn0392-856X
dc.identifier.doi10.55563/clinexprheumatol/3nuz51
dc.identifier.urihttp://hdl.handle.net/10072/411272
dc.description.abstractOBJECTIVES: To evaluate the impact of secukinumab on nail psoriasis and other psoriatic disease manifestations in patients with psoriatic arthritis (PsA) with concomitant nail psoriasis from the FUTURE 5 study. METHODS: Eligible patients were randomly allocated to receive subcutaneous secukinumab (300 mg load [300 mg], 150 mg load [150 mg], and 150 mg [no load]) or placebo weekly and then every 4 weeks starting Week 4. Key assessments through Week 104 in this post hoc analysis included modified Nail Psoriasis Severity (mNAPSI), Psoriasis Area and Severity Index (PASI 90), resolution of dactylitis and enthesitis, Dermatology Life Quality Index (DLQI) and radiographic progression (assessed by vdH-mTSS). RESULTS: At baseline, 66.6% patients (663/996) had concomitant nail psoriasis. Baseline characteristics were balanced in the nail subset and comparable with the overall population. Secukinumab reduced mNAPSI score at Week 16 versus placebo: -8.71 (300 mg), -8.95 (150 mg), -7.55 (150 mg no load) versus -2.34 (placebo); all p<0.0001. Mean change from baseline in DLQI at Week 16 was -8.5 (300 mg), -7.4 (150 mg), -7.3 (150 mg no load) versus -2.4 (placebo); all p<0.0001. Overall, the improvements reported at Week 16 sustained through Week 104. The proportion of patients with no radiographic progression (change from baseline in vdH-mTSS≤0.5) at Week 104 was 91.9% (300 mg) 78.9% (150 mg), and 82.4% (150 mg no load). CONCLUSIONS: Secukinumab provided sustained improvements in nail disease, signs and symptoms of PsA, and a low rate of radiographic progression through 2 years in patients with concomitant nail psoriasis.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherClinical and Experimental Rheumatology
dc.relation.ispartofpagefrom952
dc.relation.ispartofpageto959
dc.relation.ispartofissue5
dc.relation.ispartofjournalClinical and Experimental Rheumatology
dc.relation.ispartofvolume40
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3202
dc.titleSecukinumab provides sustained improvement in nail psoriasis, signs and symptoms of psoriatic arthritis and low rate of radiographic progression in patients with concomitant nail involvement: 2-year results from the Phase III FUTURE 5 study
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationNash, P; Mease, PJ; Kirkham, B; Singhal, A; Quebe-Fehling, E; Pricop, L; Gaillez, C, Secukinumab provides sustained improvement in nail psoriasis, signs and symptoms of psoriatic arthritis and low rate of radiographic progression in patients with concomitant nail involvement: 2-year results from the Phase III FUTURE 5 study, Clinical and Experimental Rheumatology, 40 (5), pp. 952-959, 2022
dcterms.dateAccepted2021-04-26
dc.date.updated2021-10-22T03:23:10Z
gro.hasfulltextNo Full Text
gro.griffith.authorNash, Peter


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record