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dc.contributor.authorShaw, Peter
dc.contributor.authorRaymond, Greg
dc.contributor.authorSenthilnathan, Raghul
dc.contributor.authorKumarasamy, Chellan
dc.contributor.authorBaxi, Siddhartha
dc.contributor.authorSuresh, Deepa
dc.contributor.authorShetty, Sameep
dc.contributor.authorRam M, Ravishankar
dc.contributor.authorChandramoorthy, Harish C
dc.contributor.authorSivanandy, Palanisamy
dc.contributor.authorSamiappan, Suja
dc.contributor.authorRajagopal, Mogana
dc.contributor.authorKrishnan, Sunil
dc.contributor.authorJayaraj, Rama
dc.date.accessioned2022-01-10T06:35:41Z
dc.date.available2022-01-10T06:35:41Z
dc.date.issued2021
dc.identifier.issn2073-4425
dc.identifier.doi10.3390/genes12122029
dc.identifier.urihttp://hdl.handle.net/10072/411339
dc.description.abstractBackground: The microRNAs (miRNAs) are small noncoding single-stranded RNAs typically 19-25 nucleotides long and regulated by cellular and epigenetic factors. These miRNAs plays important part in several pathways necessary for cancer development, an altered miRNA expression can be oncogenic or tumor-suppressive. Recent experimental results on miRNA have illuminated a different perspective of the molecular pathogenesis of head and neck cancers. Regulation of miRNA can have a detrimental effect on the efficacy of chemotherapeutic drugs in both neoadjuvant and adjuvant settings. This miRNA-induced chemoresistance can influence the prognosis and survival rate. The focus of the study is on how regulations of various miRNA levels contribute to chemoresistance in head and neck cancer (HNC). Recent findings suggest that up or down-regulation of miRNAs may lead to resistance towards various chemotherapeutic drugs, which may influence the prognosis. Methods: Studies on miRNA-specific chemoresistance in HNC were collected through literary (bibliographic) databases, including SCOPUS, PubMed, Nature, Elsevier, etc., and were systematically reviewed following PRISMA-P guidelines (Preferred Reporting Items for Systematic Review and Meta-analysis Protocol). We evaluated various miRNAs, their up and downregulation, the effect of altered regulation on the patient's prognosis, resistant cell lines, etc. The data evaluated will be represented in the form of a review and meta-analysis. Discussion: This meta-analysis aims to explore the miRNA-induced chemoresistance in HNC and thus to aid further researches on this topic. PROSPERO registration: CRD42018104657.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherMDPI AG
dc.relation.ispartofpagefrom2029
dc.relation.ispartofissue12
dc.relation.ispartofjournalGenes
dc.relation.ispartofvolume12
dc.subject.fieldofresearchGenetics
dc.subject.fieldofresearchcode3105
dc.subject.keywordschemoresistance
dc.subject.keywordsdown-regulation
dc.subject.keywordshazard ratio
dc.subject.keywordshead and neck cancer
dc.subject.keywordsmiRNA
dc.titleClinical Theragnostic Relationship between Chemotherapeutic Resistance, and Sensitivity and miRNA Expressions in Head and Neck Cancers: A Systematic Review and Meta-Analysis Protocol.
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationShaw, P; Raymond, G; Senthilnathan, R; Kumarasamy, C; Baxi, S; Suresh, D; Shetty, S; Ram M, R; Chandramoorthy, HC; Sivanandy, P; Samiappan, S; Rajagopal, M; Krishnan, S; Jayaraj, R, Clinical Theragnostic Relationship between Chemotherapeutic Resistance, and Sensitivity and miRNA Expressions in Head and Neck Cancers: A Systematic Review and Meta-Analysis Protocol., Genes, 2021, 12 (12), pp. 2029
dcterms.dateAccepted2021-12-18
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/
dc.date.updated2022-01-10T04:37:50Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorBaxi, Siddhartha


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