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  • A gonococcal vaccine has the potential to rapidly reduce the incidence of Neisseria gonorrhoeae infection among urban men who have sex with men

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    Seib526098-Published.pdf (1.266Mb)
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    Accepted Manuscript (AM)
    Author(s)
    Hui, Ben B
    Padeniya, Thilini N
    Rebuli, Nic
    Gray, Richard T
    Wood, James G
    Donovan, Basil
    Duan, Qibin
    Guy, Rebecca
    Hocking, Jane S
    Lahra, Monica M
    Lewis, David A
    Whiley, David M
    Regan, David G
    Seib, Kate L
    Griffith University Author(s)
    Seib, Kate
    Year published
    2021
    Metadata
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    Abstract
    BACKGROUND: A gonococcal vaccine is urgently needed due to increasing gonorrhoea incidence and emerging multidrug-resistant gonococcal strains worldwide. Men who have sex with men (MSM) have among the highest incidences of gonorrhoea and may be a key target population for vaccination when available. METHODS: An individual-based, anatomical site-specific mathematical model was used to simulate Neisseria gonorrhoeae transmission in a population of 10,000 MSM. The impact of vaccination on gonorrhoea prevalence was assessed. RESULTS: With a gonococcal vaccine of 100% or 50% protective efficacy, gonorrhoea prevalence could be ...
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    BACKGROUND: A gonococcal vaccine is urgently needed due to increasing gonorrhoea incidence and emerging multidrug-resistant gonococcal strains worldwide. Men who have sex with men (MSM) have among the highest incidences of gonorrhoea and may be a key target population for vaccination when available. METHODS: An individual-based, anatomical site-specific mathematical model was used to simulate Neisseria gonorrhoeae transmission in a population of 10,000 MSM. The impact of vaccination on gonorrhoea prevalence was assessed. RESULTS: With a gonococcal vaccine of 100% or 50% protective efficacy, gonorrhoea prevalence could be reduced by 94% or 62%, respectively, within 2 years if 30% of MSM are vaccinated on presentation for STI testing. Elimination of gonorrhoea is possible within 8 years with vaccines of ≥50% efficacy over 2 years, providing a booster vaccination is available every 3 years on average. A vaccine's impact may be reduced if it is not effective at all anatomical sites. CONCLUSIONS: Our study indicates that with a vaccine of modest efficacy and an immunisation strategy that targets MSM presenting for STI screening, the prevalence of gonorrhoea in this population could be rapidly and substantially reduced.
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    Journal Title
    The Journal of Infectious Diseases
    DOI
    https://doi.org/10.1093/infdis/jiab581
    Copyright Statement
    © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
    Note
    This publication has been entered as an advanced online version in Griffith Research Online.
    Subject
    Clinical sciences
    Medical microbiology
    Neisseria gonorrhoeae
    gonococcal vaccine
    gonorrhoea
    individual-based model
    mathematical model
    Publication URI
    http://hdl.handle.net/10072/411457
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    • Journal articles

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